Synthesis of libraries for use in biological testing of Chagas Disease

• Grant number: 14/19221-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: April 01, 2015
• End date: January 31, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Helio Alexandre Stefani
• Grantee: Michael Nils Balfour
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

To synthesize libraries for biological testing using combinatorial chemistry. We hope to prepare different libraries making variations in aromatic, heterocyclic, acetylenic groups at position 2 and position 4 of the heterocyclic ring. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BALFOUR, MICHAEL N.; ZUKERMAN-SCHPECTOR, JULIO; DAVILA RODRIGUEZ, MARIA JOSE; REIS, JOEL SAVI; ESTEVES, CARLOS HENRIQUE A.; STEFANI, HELIO A.. Combination of Sonogashira coupling and 5-endo-dig cyclization for the synthesis of 2,6-disubstituted-5-azaindoles. Synthetic Communications, v. 49, n. 3, p. 351-358, FEB 1 2019. (14/19221-0, 16/02392-1, 17/26673-2, 17/24821-4)

VASCONCELOS, STANLEY N. S.; REIS, JOEL S.; DE OLIVEIRA, ISADORA M.; BALFOUR, MICHAEL N.; STEFANI, HELIO A.. Synthesis of symmetrical biaryl compounds by homocoupling reaction. Tetrahedron, v. 75, n. 13, p. 1865-1959, MAR 29 2019. (13/17960-7, 16/04289-3, 17/24821-4, 14/19221-0, 16/02392-1)