Lead exposure in household and school settings: comparison among different blood lead levels

• Grant number: 14/22118-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2015
• End date: December 31, 2015
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Kelly Polido Kaneshiro Olympio
• Grantee: Flavio Ferreira Bezerra
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Lead (Pb) is widely known as a ubiquitous and highly toxic metal to human health. In Brazil, there are scarce data on the extension of Pb contamination in the general population, especially for the most vulnerable population, composed of preschool children. In the previous study funded by FAPESP (2011/13076-0, 2011/23272-0 and 2012/21840-4), venous blood samples of 2,463 children attending 50 Day Care Centers (DCCs) was collected in São Paulo. These blood samples were analyzed and the results are being processed. Preliminary data, including results of 1,970 children showed a geometric mean for blood lead levels of 2.2 µg/dL (95% CI: 2.1 to 2.3 µg/dL) and 97.5 percentile of 16.2 µg/dl (95% CI: 13.1 to 23.0 µg/dL). These results represent twice the geometric mean found in the United States and more than three times the reference value indicated by the Centers for Disease Control and Prevention (97.5 Percentile = 5 µg/dL). For the continuity and developing of the aforementioned research, this study will include 104 children attending 2 DCCs (one located on the east side and the other one on the south side of São Paulo), whose children had high blood lead levels, reassessing the exposure. As a general aim, ingested diet, household and school settings will be assessed. These results will be compared between two groups: high exposure (e 5 µg/dL) and low exposure (< 5 µg/dL). Descriptive statistics and multiple regression analysis will be applied to the data.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LEROUX, ISABELLE NOGUEIRA; SACONE DA SILVA FERREIRA, ANA PAULA; DA ROCHA SILVA, JULIA PRESTES; BEZERRA, FLAVIO FERREIRA; DA SILVA, FABIO FERREIRA; SALLES, FERNANDA JUNQUEIRA; LUZ, MACIEL SANTOS; DE ASSUNCAO, NILSON ANTONIO; ALVES CARDOSO, MARIA REGINA; KANESHIRO OLYMPIO, KELLY POLIDO. Lead exposure from households and school settings: influence of diet on blood lead levels. Environmental Science and Pollution Research, v. 25, n. 31, SI, p. 31535-31542, NOV 2018. (14/20945-2, 12/21840-4, 14/22118-6, 15/01395-4, 11/23272-0)

LEROUX, ISABELLE NOGUEIRA; SACONE DA SILVA FERREIRA, ANA PAULA; DA ROCHA SILVA, JULIA PRESTES; BEZERRA, FLAVIO FERREIRA; DA SILVA, FABIO FERREIRA; SALLES, FERNANDA JUNQUEIRA; LUZ, MACIEL SANTOS; DE ASSUNCAO, NILSON ANTONIO; ALVES CARDOSO, MARIA REGINA; KANESHIRO OLYMPIO, KELLY POLIDO. Lead exposure from households and school settings: influence of diet on blood lead levels. Environmental Science and Pollution Research, v. 25, n. 31, p. 8-pg., 2018-11-01. (11/23272-0, 14/20945-2, 12/21840-4, 15/01395-4, 14/22118-6)