Arterial wall injury induced by aortic cross clamping during aortic surgery: changes on morphometric and biomechanical properties of the aorta in a porcine experimental model

• Grant number: 14/13616-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2015
• End date: April 30, 2016
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Winston Bonetti Yoshida
• Grantee: Marcela Polachini Prata
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Infrarenal cross clamping during aortic surgery induces production of reactive oxygen species and complex hemodynamic disturbances that may impair renal function postoperatively. Minimally invasive methods could course with lower morbidity and mortality in surgeries involving aortic flow interruption. The aim of this study is evaluate the structural changes of the aortic wall caused by aortic clamping depending on the surgical approach used for exposure and disruption of aortic flow: median laparotomy, endovascular procedure or laparoscopic surgery.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARCELA POLACHINI PRATA; RODRIGO GIBIN JALDIN; PEDRO LUIZ TOLEDO DE ARRUDA LOURENÇÃO; MARCONE LIMA SOBREIRA; RICARDO DE ALVARENGA YOSHIDA; SIMONE ANTUNES TERRA; ROSA MARLENE VIERO; WINSTON BONETTI YOSHIDA. Lesão aguda da parede arterial provocada pelo método de interrupção temporária de fluxo em diferentes vias de cirurgia aórtica: estudo morfológico e biomecânico da aorta de porcos. Jornal Vascular Brasileiro, v. 19, 2020-04-03. (14/13616-2)