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Analysis of the relationship between central obesity and patients with aortic aneurysms

Grant number: 14/18276-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2015
Effective date (End): April 30, 2016
Field of knowledge:Health Sciences - Medicine - Surgery
Principal researcher:Antonio Eduardo Zerati
Grantee:Taina Curado Gomes de Barros
Home Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The pathogenesis of aneurysm growth of infrarenal abdominal aortic aneurysm (AAA) is not yet fully defined. Important factors are inflammatory markers such as interleukin-6 and metalloproteinase inducer specific degradation of collagen and elastin in the aortic wall. Drugs of anti-inflammatory action, such as statins, are associated with reduced growth rate of aneurysm also decreasing perioperative morbidity and mortality due to cardiovascular events. All arteries including the aorta, are surrounded by perivascular adipose tissue. It is believed that this inflammatory perivascular tissue produce substances which may be involved in, main cause of aortic aneurysms degenerative arterial disease. The way the fat is distributed may be assessed by anthropometric study of adiposity made by measuring waist circumference and waist-hip ratio. The phase of respiration (inspiration or expiration) at the time of measurement, more or less bloating changing the circumference not related to the amount of visceral fat and the placement of the tape measure way are factors that can cause oscillation in anthropometric measures. Already computed tomography method of choice for evaluation of patients with abdominal aortic aneurysm, can be used to measure visceral fat volume and area, providing greater accuracy in measurements, and allows to differentiate subcutaneous fat in intra-abdominal. Objectives: The aim of this study is to identify the profile of central obesity in patients with abdominal aortic aneurysms. Another objective is to study the relationship of abdominal fat with aneurysm as maximum transverse diameter. Materials and methods: CT scans of the abdomen of 300 consecutive patients followed will be evaluated at the Clinic of the Department of Aneurysms Vascular and Endovascular Surgery, Hospital das Clinicas, Faculty of Medicine, University of São Paulo treated between January 1, 2012 and 30 June 2014 Osirix® Using the program, the area of subcutaneous fat and the area of intra-abdominal fat in patients with abdominal aortic aneurysm will be determined, beyond the maximum transverse diameter of the infrarenal aorta in milímietros. Profile of central obesity based on average areas of visceral fat and subcutaneous fat of patients with small aneurysms (30 to 50mm), medium (51 to 60mm) and large (e 61mm) will be determined.

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