Prevalence of abdominal aortic aneurysm in patients with solid tumors and evaluation of the aneurysm diameter in patients under chemotherapy

• Grant number: 12/20317-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2013
• End date: January 31, 2014
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: ANTONIO EDUARDO ZERATI
• Grantee: Marianna Almeida Hollaender
• Host Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

There are studies in the literature showing that changes in the endothelial function can be caused by chemotherapy, with reports of individuals who developed aortic dissection during cancer treatment. The influence of chemotherapy on the growth and risk of aneurysm rupture is not defined, particularly in dilatation of the abdominal aorta, which are the most frequent. This relationship can influence early indication of surgical treatment of aortic aneurysms in patients in whom chemotherapy is planned, which explains the relevance of this study. Thus, considering that cancer and aortic aneurysms are diseases that affect patients of similar age, it is important to know the prevalence of abdominal aortic aneurysms in patients with solid tumors and the behavior of these aneurysms in patients under chemotherapy. The objective of this study is to determine the prevalence of abdominal aortic aneurysms in patients undergoing cancer treatment for solid tumors at the Cancer Institute of the State of São Paulo (ICESP) admitted between January to June 2010. The other goal is to verify the evolution of the size of the aneurysm in patients undergoing chemotherapy.(AU)