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Abdominal aortic aneurysm induction - an endovascular model in pigs

Grant number: 10/07307-6
Support type:Regular Research Grants
Duration: December 01, 2010 - November 30, 2011
Field of knowledge:Health Sciences - Medicine - Surgery
Principal researcher:Erasmo Simão da Silva
Grantee:Erasmo Simão da Silva
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Alex Lederman ; Igor Rafael Sincos ; Ricardo Aun

Abstract

Abdominal aortic aneurysms are the 10th cause of death in the United States. With the aging of the population and better diagnostics methods there has been a rise in aneurysms diagnosis in the past years. The high mortality associated with aneurysms ruptures and morbidity associated with treatment, makes aneurysms a great challenge to surgeons and a high risk for patients. Experimental models may become useful tools in the understanding, management, treatment, training and developing techniques and materials for this pathology.All models up to now have many flaws. Either they are in small animals, or they are made through laparotomy or the aortic behavior does not resemble a true aneurysm. This study's goal is to develop an experimental model of infra-renal aortic aneurysm in White Large pigs, through an endovascular approach.Materials and Methods: 18 Large White pigs will be separated in 3 groups of 6 animals each. The control group will be exposed to saline solution (0.9%). Group 1 will be exposed to Calcium Chloride (5 molar), while group 2 will be exposed to elastase. All animals will be operated by the same surgical technique, under general anesthesia. They will be followed with weekly ultrasound exams and at 4 weeks, under general anesthesia the aorta will be harvested, and submitted to biomechanical and histological analysis.As seen in the previous models, we believe that the exposure to the chemicals will induce aneurysm formation and the endovascular approach will not cause retroperitoneal fibrosis, as previously seen. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEDERMAN, ALEX; SALITURE NETO, FERNANDO TAVARES; FERREIRA, RIMARCS; POLI DE FIGUEIREDO, LUIS FRANCISCO; OTOCH, JOSE PINHATA; AUN, RICARDO; DA SILVA, ERASMO SIMAO. Endovascular model of abdominal aortic aneurysm induction in swine. VASCULAR MEDICINE, v. 19, n. 3, p. 167-174, JUN 2014. Web of Science Citations: 5.

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