Effect of curcumin on inflammatory and metabolic parameters in obese mice

• Grant number: 14/03503-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2015
• End date: November 30, 2017
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Camila Renata Corrêa
• Grantee: Ângelo Thompson Colombo Lo
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Obesity is a worldwide public health problem, especially due to changing eating habits and lack of exercise practices physical. The white adipose tissue (WAT ) is an endocrine organ with actions complex metabolic , this set of effects leads to comorbidities such as Metabolic syndrome (MS ), which are a set of endocrine factors and Metabolic such as insulin resistance, high blood pressure, hyperglycemia, hypertriglyceridemia and inflammation. Curcumin is a polyphenol natural origin, is a condiment used in cooking and already own actionantiinflammatory . The objective will be to test whether supplementation with Curcumin is able to reduce the inflammatory profile in adipose tissue and plasma, together with the improvement of the metabolic profile of animals .The animals will be initially divided randomly into two groups( n = 30 animals / group ) to receive standard diet ( P ) + water or standard diet Water + 30% fructose (PF) for 15 weeks . After this period the animals will again be divided to receive 300mg/kg of curcumin or placebo for 12 weeks, then making four experimental groups independent ( P , P + curcumin , PF , PF + curcumin , n = 15 animals/ group). The Obesity is characterized by adiposity index, comorbidities: systemic blood pressure, glycemic, lipid, inflammatory and hormonal profiles ;oral glucose tolerance test will be analyzed. Statistical analysis will be performed according to the status of the data obtained during the search.