Does it matter that my knee clicks? a longitudinal study of functional decline based on the presence of CREPITUS: data from the osteoarthritis initiative

• Grant number: 15/10631-3
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: August 01, 2015
• End date: October 31, 2015
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Fábio Mícolis de Azevedo
• Grantee: Marcella Ferraz Pazzinatto
• Supervisor: Evangelos Pappas
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Institution abroad: University of Sydney, Australia
• Associated to the scholarship: 14/10839-0 - Influence of pain on electromyographic parameters in subjects with patellofemoral pain syndrome during stair climbing: frequency and time domain, BP.MS

Abstract

Knee Osteoarthritis (OA) is a major cause of functional disability; around 80% of those with OA have movement limitations. The diagnosis of knee OA may take into account symptoms and signs. Therefore, thorough clinical assessment alone can provide a confident diagnosis without need a radiographic examination. Crepitus or crepitation in association with knee OA is defined as a crackling or grinding sound on joint movement. Given the importance of crepitus as a prognostic and diagnostic factor for knee OA, it is surprising that no studies to our knowledge have investigated the association between knee crepitus and functional limitations. As the presence of knee crepitus is one of the six criteria used for the clinical diagnosis of OA, it is important to understand if presence of crepitus is associated with functional decline in people with knee OA. As testing for crepitus is quick and easy at a clinical setting, the findings of this study will provide important information to clinicians who examine patients with OA or those who are at high risk of developing knee OA. However, only a longitudinal study can determine if the presence of knee crepitus is associated with a quicker functional decline or with development of knee OA. This study will be conducted using the OAI database at 4-years follow up. The data of all participants with possible or definite knee OA bilaterally will be analyzed. It will be defined as having a possible or definite osteophyte in knees on weight-bearing radiographs. The variables will include knee crepitus, physical summary scale for the medical outcome scale 12 item short-form health survey (SF-12), Knee injury and Osteoarthritis Outcome Score function, sports and recreational activities (KOOS-FSR), Western Ontario and McMaster Universities (WOMAC) disability subscale, Kellgren-Lawrence (K-L) grade, 20-meter walk test, quality of life subscale of the KOOS, WOMAC pain subscale and isometric strength for knee flexion and extension, and also occurrence of Total knee replacement. A mixed Multivariate Analysis of co-Variance (MANCOVA) test will be performed for comparison of global (i.e. SF-12, KOOS function, sports and recreational activities, KOOS of quality of life and walk test of 20 meters) and specific variables (WOMAC pain, WOMAC disability, K-L grade, occurrence of TKR and isometric strength) between groups and in different timelines of each group (baseline, 1 year, 2 years, 3 years and 4 years follow-up). Gender, age and BMI will be used as covariates. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PAZZINATTO, MARCELLA FERRAZ; SILVA, DANILO DE OLIVEIRA; FERREIRA, AMANDA SCHENATTO; WAITEMAN, MARINA CABRAL; PAPPAS, EVANGELOS; MAGALHAES, FERNANDO HENRIQUE; DE AZEVEDO, FABIO MICOLIS. Patellar Tendon Reflex and Vastus Medialis Hoffmann Reflex Are Down Regulated and Correlated in Women With Patellofemoral Pain. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, v. 100, n. 3, p. 514-519, MAR 2019. (14/10839-0, 16/19784-0, 16/50320-0, 15/10631-3)

PAZZINATTO, MARCELLA FERRAZ; SILVA, DANILO DE OLIVEIRA; FARIA, NATHALIE CLARA; SIMIC, MILENA; FERREIRA, PAULO HENRIQUE; DE AZEVEDO, FABIO MICOLIS; PAPPAS, EVANGELOS. What are the clinical implications of knee crepitus to individuals with knee osteoarthritis? An observational study with data from the Osteoarthritis Initiative. BRAZILIAN JOURNAL OF PHYSICAL THERAPY, v. 23, n. 6, p. 491-496, NOV-DEC 2019. (15/11534-1, 15/10631-3)

PAZZINATTO, MARCELLA FERRAZ; SILVA, DANILO DE OLIVEIRA; DE AZEVEDO, FABIO MICOLIS; PAPPAS, EVANGELOS. Knee crepitus is not associated with the occurrence of total knee replacement in knee osteoarthritis - a longitudinal study with data from the Osteoarthritis Initiative. BRAZILIAN JOURNAL OF PHYSICAL THERAPY, v. 23, n. 4, p. 329-336, JUL-AUG 2019. (15/10631-3, 15/11534-1)