Study of the role of histamine receptors involved in the regulation of atrial function in Wistar-EPM1 and STZ-diabetic rats

• Grant number: 15/03490-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2015
• End date: May 31, 2017
• Field of knowledge: Biological Sciences - Pharmacology - Autonomic Pharmacology
• Principal Investigator: Neide Hyppolito Jurkiewicz
• Grantee: Sthefani Rodrigues Nascimento
• Host Institution: Instituto Nacional de Farmacologia (INFAR). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Diabetes is a disease that affects the world population. An important factor in diabetics is the cardiovascular risk since a large part of this population ends and dies of a cardiovascular event. Among the most common changes in the cardiovascular system in diabetics is the change in the peripheral nervous system, especially the sympathetic nervous system. Because of this, it is essential to study the control of this system in diabetics. Recently the literature has brought a major role in inflammatory factors, such as histamine, has in this system because it can be released by sympathetic neurons with norepinephrine, moreover, it is also increased in some pathological conditions, such as in diabetes. Therefore, we intend to induce diabetes in male Wistar rats by streptozotocin (60 mg/kg) and to verify the function of histaminergic receptors in isolated atria from normoglycemic and diabetic rats.