| Grant number: | 15/11359-5 |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| Start date: | August 15, 2015 |
| End date: | February 14, 2016 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Organic Chemistry |
| Principal Investigator: | Ljubica Tasic |
| Grantee: | Banny Silva Barbosa Correia |
| Supervisor: | Valerie B. Odonnell |
| Host Institution: | Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
| Institution abroad: | Cardiff University, Wales |
| Associated to the scholarship: | 13/14707-9 - lipidomic analysis of some Amazonian fish, BP.DR |
Abstract The metabolism of phospholipids have been related to many neurological disorders. This relation is because the nervous system has the second highest levels of lipids in human body, emphasizing the importance of the role of metabolism lipid. Nowadays, the therapeutic for this diseases are made by psychotropic drugs and is believed that the efficiency is influenced by the level of polyunsaturated fatty acids (PUFAs) at specific phospholipid. Thus, administration of particular phospholipids with side chain of PUFAs can be alternative therapy and therefore to investigate different existing phospholipids candidates in nature for this treatment is a key step not only to contribute to the process of nutritional formulations but for knowledge of ecology chemistry. Amazonian fish are one of these tools of nature that have possible phospholipids of interest, especially glycerophosphoserine and glycerophosphocholine. As one of the very important factors that influence the distribution of lipids in Amazonian fishes is their eating behavior, which is often affected by the seasonal dynamics of the Amazon River, the variety of phospholipids that are possible to found in this fishes is wide. However determine the lipid composition in biological matrix is not trivial, since the wide diversity of molecules difficult to separate and identify, however, one of the more recent alternative is Lipidomics. The Lipidomics is a lipid analysis tool in biological system which determine them in their intact form, doing characterization, detection and quantification. It is a process analogous to proteomic studies, conducted by the sum of all kinds of lipids. A prominent technique in this field is the Mass Spectrometry, which in the case to investigate specific phospholipid is combined with Liquid chromatography and uses the approach "Target Lipidomic" - a technique that looks for a specific lipid or lipid class in tissue or cell extract detecting compounds at low levels compared to other species of lipids. Thus, It aims to evaluate using "Target Lipidomic" by Mass Spectrometry phospholipids of the muscles and livers of nine species of the Amazonian fishes that were collected from River Amazon in two periods, flood and drought, during two consecutive years. The fishes had different eating habits and could be classified as omnivorous, detrivorous, piscivorous, planktivorous and carnivorous. (AU) | |
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