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New functional aspects of eicosanoids

Grant number: 15/00658-1
Support type:Multi-user Equipment Program
Duration: March 01, 2016 - February 28, 2018
Field of knowledge:Biological Sciences - Immunology
Principal Investigator:Lúcia Helena Faccioli
Grantee:Lúcia Helena Faccioli
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/07125-6 - New functional aspects of eicosanoids, AP.TEM
EMU web page: Página do Equipamento Multiusuário não informada
Use scheduling: E-mail de agendamento não informado

Abstract

Mass spectrometry is a highly sensitive, selective and rapid technique for characterizing multiple species of lipids, simultaneously, without the need for prior isolation and derivatization of compounds of interest. Coupled to ultra-pressure liquid chromatography (UHPLC-MS) is a powerful tool for identification, characterization and quantification of lipid mediators in complex matrices, allowing identification of lipid regiosomers. Lipidomics is the identification and quantification of lipids in biological systems, being the same, as a tool to evaluate the profile of certain lipid classes in immune and inflammatory responses. In our projects, we will focus our analysis to the class of eicosanoids, membrane phospholipids and neutral lipids. The formation of the Centre of Excellence for Quantification and Identification of Lipids (CEQIL), justifies the request of UHPLC-MS/MS system for this purpose. So, by being the first Lipid Analysis Center, using this technology in Brazil, this equipment (mass spectrometer) will have multiuser character, allowing the insertion of the quantification and identification of lipids in various interest projects such as biotechnology, clinical and basic research. So even being targeted primarily to analysis of a class of biomolecules (lipids), the use of the equipment will be constant and will have high demand, allowing the generation of new knowledge, scientific articles of impact and technological advances. (AU)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOCACHEVIC, GISELE A.; PRADO, MORGANA K. B.; ZOCCAL, KARINA F.; PEREIRA, PRISCILLA A. T.; SORGI, CARLOS A.; BORTOLANZA, MARIZA; PETI, ANA PAULA F.; FOGACA, MANOELA V.; GUIMARAES, FRANCISCO S.; DEL BEL, ELAINE; FACCIOLI, LUCIA H. Paradoxical Effect of LTB4 on the Regulation of Stress-Induced Corticosterone Production. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 13, APR 16 2019. Web of Science Citations: 1.
ZOCCAL, KARINA F.; GARDINASSI, LUIZ G.; BORDON, KARLA C. F.; ARANTES, ELIANE C.; MARLEAU, SYLVIE; ONG, HUY; FACCIOLI, LUCIA H. EP80317 Restrains Inflammation and Mortality Caused by Scorpion Envenomation in Mice. FRONTIERS IN PHARMACOLOGY, v. 10, MAR 1 2019. Web of Science Citations: 1.
ESTEVES, ELIANE; BIZZARRO, BRUNA; COSTA, FRANCISCO BORGES; RAMIREZ-HERNANDEZ, ALEJANDRO; FERRANTI PETI, ANA PAULA; DEPIERI CATANEO, ALLAN HENRIQUE; WOWK, PRYSCILLA FANINI; TIMOTEO, RODOLFO PESSATO; LABRUNA, MARCELO BAHIA; SILVA JUNIOR, PEDRO ISMAEL; SILVA, CELIO LOPES; FACCIOLI, LUCIA HELENA; FOGACA, ANDREA CRISTINA; SORGI, CARLOS ARTERIO; SA-NUNES, ANDERSON. Amblyomma sculptum Salivary PGE(2) Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo. FRONTIERS IN IMMUNOLOGY, v. 10, FEB 4 2019. Web of Science Citations: 0.
PAULA, T. D.; SILVA, B. R.; GRANDO, M. D.; SOUZA, H. C. D.; BENDHACK, L. M. Activation of TP receptors induces high release of PGI(2) in coronary arteries of renal hypertensive rats. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, v. 122, p. 125-133, SEP 2018. Web of Science Citations: 1.
SOUZA, CAMILA O. S.; ESPINDOLA, MILENA S.; FONTANARI, CAROLINE; PRADO, MORGANA K. B.; FRANTZ, FABIANI G.; RODRIGUES, VANDERLEI; GARDINASSI, LUIZ G.; FACCIOLI, LUCIA H. CD18 Regulates Monocyte Hematopoiesis and Promotes Resistance to Experimental Schistosomiasis. FRONTIERS IN IMMUNOLOGY, v. 9, AUG 31 2018. Web of Science Citations: 1.
SORGI, CARLOS ARTERIO; FERRANTI PETI, ANA PAULA; PETTA, TANIA; GALVAO MEIRELLES, ALYNE FAVERO; FONTANARI, CAROLINE; BERALDO DE MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays. SCIENTIFIC DATA, v. 5, AUG 21 2018. Web of Science Citations: 1.
FERRANTI PETI, ANA PAULA; LOCACHEVIC, GISELE APARECIDA; BORGES PRADO, MORGANA KELLY; BERALDO DE MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. High-resolution multiple reaction monitoring method for quantification of steroidal hormones in plasma. Journal of Mass Spectrometry, v. 53, n. 5, p. 423-431, MAY 2018. Web of Science Citations: 3.
ZOCCAL, KARINA F.; GARDINASSI, LUIZ G.; SORGI, CARLOS A.; MEIRELLES, ALYNE F. G.; BORDON, KARLA C. F.; GLEZER, ISAIAS; CUPO, PALMIRA; MATSUNO, ALESSANDRA K.; BOLLELA, VALDES R.; ARANTES, ELIANE C.; GUIMARAES, FRANCISCO S.; FACCIOLI, LUCIA HELENA. CD36 Shunts Eicosanoid Metabolism to Repress CD14 Licensed Interleukin-1 beta Release and Inflammation. FRONTIERS IN IMMUNOLOGY, v. 9, APR 27 2018. Web of Science Citations: 4.
SORGI, CARLOS A.; ZARINI, SIMONA; MARTIN, SARAH A.; SANCHEZ, RAPHAEL L.; SCANDIUZZI, RODRIGO F.; GIJON, MIGUEL A.; GUIJAS, CARLOS; FLAMAND, NICOLAS; MURPHY, ROBERT C.; FACCIOLI, LUCIA H. Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid. SCIENTIFIC REPORTS, v. 7, SEP 8 2017. Web of Science Citations: 8.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.