Study of an small heat shock protein expression in the Malaria rodent model

• Grant number: 15/04005-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2015
• End date: May 31, 2016
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: Georgina Nuri Montagna
• Grantee: Gesislania de Sousa
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 13/14361-5 - Plasmodium parasite motility: identification of new candidates for drug targeting and validation of vaccine candidates, AP.JP

Abstract

We had previously identified a heat shock protein involved in the migration and natural transmission of the malaria parasite. To further characterize the regulation of the molecular motor, we search for additional members of this family protein. A new small chaperone protein was identified, which is expressed at different parasite stages. Interestingly, this molecule of 17 kDa (Hsp17) is possibly found in Plasmodium erythrocityc stages and involved during parasite development. We propose to analyze the expression and localization of Hsp17 protein during Plasmodium berghei life cycle.