Osteochondral lesions treatment with parylene

• Grant number: 15/08952-6
• Support Opportunities: Scholarships abroad - Research
• Start date: August 01, 2015
• End date: July 31, 2016
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: CARLOS EDUARDO DA SILVEIRA FRANCIOZI
• Grantee: CARLOS EDUARDO DA SILVEIRA FRANCIOZI
• Host Investigator: James Eugene Tibone
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Institution abroad: University of Southern California (USC), United States

Abstract

Cartilage lesions have a low potential for healing due to its avascular nature and hypocellularity. Consequently, they tend to become symptomatic and progress with joint degeneration leading ultimately to the development of arthrosis. Despite the many existing surgical treatments for chondral lesions, there is no gold standard. Results worse along time and the formation of fibrocartilage, instead normal articular cartilage, leads to degeneration since it has inferior biomechanical properties. Since the second-generation autologous chondrocyte transplantation, the development of scaffolds for the treatment of chondral and osteochondral lesions underwent rapid growth gaining importance and popularity represented by the emergence of a myriad of materials and techniques. Scaffold based regenerative procedures are interesting because the scaffold provides a three-dimensional structure that mimics the organizational structure of the cartilage allowing the growth of living cells. The parylene-C is a biocompatible polymer approved for chronic implantation in the human body. With submicron thickness, obtained through a specific production process, it was demonstrated that this membrane allows diffusion of nutrients and macromolecules. This polymer appears to be a good option for the treatment of chondral injuries. Sixty knees of 30 rabbits will be operated. There will be four treatment groups: Group N - control with spontaneous repair. Group P - parylene scaffold. Group CP - parylene scaffold and minced autologous cartilage. Group C - minced autologous cartilage. The results will be histologically evaluated analyzing the biocompatibility, the presence of debris, tosteochondral scaffold integration, the quality of the repair tissue by O'Driscoll scale and the effect of parylene at the opposing cartilage. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE CARVALHO, ROGERIO TEIXEIRA; FRANCIOZI, CARLOS EDUARDO; ITAMI, YASUO; MCGARRY, MICHELLE H.; MCNEILL INGHAM, SHEILA JEAN; ABDALLA, RENE JORGE; TIBONE, JAMES EUGENE; LEE, THAY Q.. Bicruciate lesion biomechanics, Part 1-Diagnosis: translations over 15 mm at 90 degrees of knee flexion are indicative of a complete tear. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, v. 27, n. 9, p. 2927-2935, SEP 2019. (15/10317-7, 15/08952-6)

FRANCIOZI, CARLOS EDUARDO; DE CARVALHO, ROGERIO TEIXEIRA; ITAMI, YASUO; MCGARRY, MICHELLE H.; MCNEILL INGHAM, SHEILA JEAN; ABDALLA, RENE JORGE; TIBONE, JAMES EUGENE; LEE, THAY Q.. Bicruciate lesion biomechanics, Part 2-treatment using a simultaneous tensioning protocol: ACL fixation first is better than PCL fixation first to restore tibiofemoral orientation. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, v. 27, n. 9, p. 2936-2944, SEP 2019. (15/10317-7, 15/08952-6)

DA SILVEIRA FRANCIOZI, CARLOS EDUARDO; VANGSNESS, JR., CARLETON THOMAS; MARTINEZ, JUAN CARLOS; RODGER, DAMIEN; CHOU, TZU-CHIEH; TAI, YU-CHONG; BRANT, RODRIGO; WU, LING; ABDALLA, RENE JORGE; HAN, BO; et al. Parylene scaffold for cartilage lesion. BIOMEDICAL MICRODEVICES, v. 19, n. 2, JUN 2017. (15/08952-6)