Effects of increased dopamine transmission during the adolescent period on sexual behavior of adult rats

• Grant number: 15/02036-8
• Support Opportunities: Scholarships in Brazil - Master
• Start date: July 01, 2015
• End date: February 29, 2016
• Field of knowledge: Biological Sciences - Physiology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Monica Levy Andersen
• Grantee: Jhon Helbert Soterio Pires
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The mesolimbic dopaminergic system may suffer alterations due to internal or external stimuli. This system is activated by both, stressors or rewarding factors. In adolescence, the nervous system suffers several transformations, which occur in combination with high expression of receptors. The mesolimbic dopaminergic system presents great expression of D1 and D2 receptors. This project aims to evaluate the effects of increased dopaminergic mesolimbic transmission during adolescence in the sexual behavior of adult rats. Male rats will be exposed to activators factors of the mesolimbic pathway (cocaine, apomorphine, sleep restriction and receptive female) during the adolescence (30th to 51st day). In adulthood (75 day) all rats will be evaluated for behaviors that lead to the activation of mesolimbic dopaminergic system, such as sexual behavior. Our hypothesis is that the increase of dopaminergic transmission during adolescence would cause deep damage to dopaminergic mesolimbic system leading to a decrease in the performance of sexual behavior (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

HIROTSU, C.; SOTERIO-PIRES, J. H.; TUFIK, S.; ANDERSEN, M. L.. Sleep disturbance and sexual dysfunction in postmenopausal women. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, v. 29, n. 3, p. 126, MAY-JUN 2017. (15/02036-8, 14/15259-2)

FRANGE, C.; HIROTSU, C.; HACHUL, H.; PIRES, J. S.; BITTENCOURT, L.; TUFIK, S.; ANDERSEN, M. L.. Musculoskeletal pain and the reproductive life stage in women: is there a relationship?. CLIMACTERIC, v. 19, n. 3, p. 279-284, JUN 2016. (14/15259-2, 15/02036-8, 14/18722-5)

SOTERIO-PIRES, J. H.; HIROTSU, C.; KIM, L. J.; BITTENCOURT, L.; TUFIK, S.; ANDERSEN, M. L.. The interaction between erectile dysfunction complaints and depression in men: a cross-sectional study about sleep, hormones and cl uality of life. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, v. 29, n. 2, p. 70-75, MAR-APR 2017. (15/02036-8, 15/19136-5)