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Analysis of DNA methylation patterns associated with cattle submitted adaptation to stress heat

Grant number: 15/08553-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2015
Effective date (End): September 30, 2018
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:José Fernando Garcia
Grantee:Ludmilla Balbo Zavarez
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

The rapid adaptability of an animal to climate change directly reflects the dynamics of livestock as it affects the animal protein production, where demand increases faster than supply, driven by human population growth and eating habits change. Specifically, the thermal stress can directly affect the physiological mechanisms for, among other mechanisms, epigenetic change patterns of an animal, interfering with the expression of certain genes in DNA methylation patterns and chromatin associated proteins. This project aims develop a DNA methylation atlas in different biological tissues (blood, skin, muscle, fat, thyroid, liver and hypothalamus / pituitary) of beef cattle, from comparing the Nelore (Bos indicus) and Angus (Bos taurus), submitted or not to heat exposure for induction of heat stress. By means of the experimental design, intend to investigate the biological mechanisms, genes involved in heat tolerance and the role of DNA methylation in high adaptability and production of Bos indicus in tropical environments compared to Bos taurus. Keyword: Adaptation, Bos indicus, Bos taurus, epigenômica, heat stress, animal reproduction (AU)

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ZAVAREZ, Ludmilla Balbo. Análise de perfis epigenômicos em células nucleadas do sangue durante a exposição ao calor em bovinos das raças angus e nelore. 2018. Doctoral Thesis - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Agrárias e Veterinárias..

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