Clinical and laboratory profile of the participants of progredir cohort: risk factors associated with Chronic Kidney Disease

• Grant number: 15/10285-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2015
• End date: July 31, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Silvia Maria de Oliveira Titan
• Grantee: Estela Mion Petrillo
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Chronic kidney disease (CKD) is a growing public health problem, as well as the number of patients requiring renal replacement therapy, is an independent risk factor for cardiovascular diseases. The cost associated with the treatment reaches about 10% of the NHS budget. Preventive actions are imperative, and it is necessary to better understand the mechanisms involved in the progression of CKD. Disturbances of phosphorus, vitamin D, parathyroid hormone, FGF-23 act as markers of the risk of progression and cardiovascular events, and are possibly related to the pathogenesis of CKD and atherosclerosis. The Progredir cohort study, with its baseline conducted between 2012-2013, comprises a longitudinal study in patients with CKD coming from the Hospital das Clinicas - FMUSP. In this project, we propose to evaluate the clinical and laboratory data of the cohort baseline. Among the many variables to be analyzed in relation to renal function, we evaluate data prior history, anthropometry, classic cardiovascular risk factors, risk factors related to uremia (mineral metabolism, metabolic acidosis and anemia), and pre-clinical measures of atherosclerosis, such as calcium score in coronary, carotid intimal media thickness-media and pulse wave velocity.