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Correlation between neuropsychological performance of executive functions and structural changes in MRI in patients with epilepsy associated with unilateral temporal sclerosis

Grant number: 14/13626-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2015
Effective date (End): March 31, 2017
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Luiz Henrique Martins Castro
Grantee:Gabriel Erra Ramos
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

SUMMARY: The temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) is the most common form of intractable epilepsy and manifests with changes in episodic memory, as is already known for some time, and executive functions, which are being studied more today. The evidence on anatomical changes in temporal and extratemporal structures and the correlation with mental retardation are still limited and we know little about the way in which the pathology of the hippocampus affects daily activities. With a multiple approach, we seek to correlate volumetry of temporal and extratemporal structures and measures the integrity of white matter tracts with neuropsychological performance in executive functions in patients with unilateral mesial temporal sclerosis, right or left.