| Grant number: | 15/15562-0 |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| Start date: | October 01, 2015 |
| End date: | March 31, 2016 |
| Field of knowledge: | Biological Sciences - Microbiology - Applied Microbiology |
| Principal Investigator: | Rita de Cássia Café Ferreira |
| Grantee: | Milene Tavares Batista |
| Supervisor: | Stephen Albert Johnston |
| Host Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Institution abroad: | Arizona State University, Tempe (ASU), United States |
| Associated to the scholarship: | 12/51189-3 - Bacillus subtilis as a platform for mucosal vaccines development against human dental caries, BP.PD |
Abstract Despite of huge efforts in the last four decades to develop a vaccine against human dental caries any product is available for use in humans. In part, the failure of the strategies can be attributed to the absence of detailed knowledge of what would be a protective immune response against the pathogen, lack of a promising target antigen and correlates of protection that can be safely used to indicate the effectiveness of a vaccination strategy. We have showed that a recombinant P1 fragment (P139-512) is a promising target vaccine, able to induce antibodies that interfere with S. mutans adhesion in vitro and in vivo in a new mice challenge developed in our laboratory. Furthermore, other P1-derivative fragment, named P3C, have been used with success as anti-caries target antigen. Together these two fragments, P139-512 and P3C, present the two known saliva binding sites described until now for S. mutans P1 protein. Thus, the aim of this project is to determine the immune signature of the antibodies directed against the P1 protein after mucosal immunization of mice, and correlate these properties with the protection of mice oral colonization by S. mutans allowing predicting promising epitopes and the efficacy of a future vaccine against human dental caries. For this, we will collaborate with Dr. Stephen Albert Johnston, at the Biodesign Institute located on the Arizona State University, USA. The knowledge generated from this research will optimize the design of vaccine formulations against dental caries as well as improve our knowledge of ours vaccine strategies, increasing the chances of success in the search for an effective vaccine. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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