STUDY OF NATURAL POLYMER MICROCAPSULES DEVELOPMENT FOR APPLICATION IN MEDICAL TEXTILES

• Grant number: 15/08845-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2015
• End date: September 30, 2017
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Silgia Aparecida da Costa
• Grantee: Caroline Santos Alves de Lima
• Host Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The textile industry seeks to reclaim the rhythm of declined business, noted mainly in developed countries due to the scenario of the world economy, through the development of textiles with higher added value. The microencapsulation is a versatile and flexible technique that presents several advantages, such as avoid that the active ingredient react with other compounds present in the system, and allow controlled release, which potentially increases the efficiency of the product. The main objective of this project is to develop microcapsules of Chitosan and alginate with incorporation of Triclosan, which has bactericidal and fungicide properties, for use in textile substrates in medical area. The microcapsules will be produced from the method of emulsification by cross-links and these will be characterized by differential scanning calorimetry (DSC), water absorption capacity and mass loss, scanning electron microscopy (SEM) and in vitro release test. Cell viability studies will be carried out by means of cultivation and expansion of fibroplastos and analysis for mobile, MTT reduction plating and Crystal Violet test. The microcapsules will be applied in woven plan, in which will be carried out physical tests of density, weight, resistance and titration of wires, according to ASTM D3775, ASTM D3776-09th, ASTM D5034 and ASTM D1059-09-01, respectively. Fabric incorporated with microcapsules will still be subjected to tests of washing (ISO 105C06: 2006), friction (AATCC 8: 2013) and fastness to perspiration (ISO 105E04: 2006). It is hoped from this study to develop a textile with bactericidal and healing properties for medical application.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALVES DE LIMA, CAROLINE SANTOS; COSTA VARCA, GUSTAVO HENRIQUE; DA COSTA, SIRLENE MARIA; FERRAZ, HUMBERTO GOMES; DA SILVA SANTOS, ANA CAROLINA; LOPES, PATRICIA SANTOS; DA COSTA, SILGIA APARECIDA. Development of natural polymeric microcapsules for antimicrobial drug delivery: triclosan loaded chitosan and alginate-based microcapsules. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v. 46, n. 9, AUG 2020. (15/08845-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

LIMA, Caroline Santos Alves de. Study of the development of microcapsules of natural polymers for application in medical textiles. 2017. Master's Dissertation - Universidade de São Paulo (USP). Escola de Artes, Ciências e Humanidades (EACH) São Paulo.