Full text
| |
| Author(s): |
Caroline Santos Alves de Lima
Total Authors: 1
|
| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Escola de Artes, Ciências e Humanidades (EACH) |
| Defense date: | 2017-09-05 |
| Examining board members: |
Silgia Aparecida da Costa;
Natalino Lourenço Neto;
João Paulo Pereira Marcicano;
Adriano Marim de Oliveira
|
| Advisor: | Silgia Aparecida da Costa |
| Abstract | |
The textile industry seeks to recover the decrease of the pace of business, noted mainly in developed countries due to the scenario of the world economy, through the development of textiles with higher added value. The microencapsulation is a versatile and flexible technique that presents several advantages such as to avoid that the active ingredient react with other compounds present in the system, and allow controlled release that potentially increases the efficiency of the product. The main objective of this work was to develop microcapsules of chitosan and alginate with incorporation of triclosan, which has bactericidal and fungicide properties, for use in textile substrates for medical uses. The microcapsules were produced from the method of emulsification and crosslinking, and characterized by Thermogravimetry (TG), Differential Scanning Calorimetry (DSC), Infrared Spectroscopy Fourier Transform (FTIR), water absorption capacity and mass loss, Scanning Electron Microscopy (SEM), bactericidal activity assay and in vitro release. After characterized, the microcapsules were impregnated in 100% cotton twill and taffeta woven. Physical tests and analysis of resistance to washing were carried out. The microcapsules produced presented spherical shape and had 80.78% of drug encapsulation efficiency. Release tests showed that the drug was not released in 24 hours, however, the material presented bactericidal activity against the gram-positive bacterium S. aureus, with inhibition halo up to 60 mm and also against the gram-negative bacterium E. coli, with halo of up to 25 mm. The results of washing resistance evaluated by SEM showed that the microcapsules did not remain in the substrate. However, the material showed antibacterial activity and may be interesting for application in disposable textiles, such as bandages used in the medical field (AU) | |
| FAPESP's process: | 15/08845-5 - STUDY OF NATURAL POLYMER MICROCAPSULES DEVELOPMENT FOR APPLICATION IN MEDICAL TEXTILES |
| Grantee: | Caroline Santos Alves de Lima |
| Support Opportunities: | Scholarships in Brazil - Master |