Expression of transcription factors associated with undifferentiated cells in the aging process of the human submandibular gland

• Grant number: 15/03967-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2015
• End date: September 30, 2017
• Field of knowledge: Biological Sciences - Morphology - Anatomy
• Principal Investigator: Marcelo Cavenaghi Pereira da Silva
• Grantee: Tamires Albuquerque Gomes
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The main function of the salivary glands is production of saliva, process that the submandibular gland, made up of acini and types of ducts, is responsible for 60 per cent about the total produced. The saliva provides protection to the oral cavity structures just as act in the tamponade and digestion, however we know that during the natural process of aging, the flow of saliva decreases, this fact happens because there are a acini reduction and dilatation of the extralobular duct. This study aims to characterize the morphological changes of adult and elderly human submandibular glands through histology and Immunohistochemistry for transcription factor SOX-2, OCT-4, NANOG, STAT-3,c-kit and musashi-1 related to cellular differentiation and pluripotency in the same way to the growth factor EGF.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GOMES, TAMIRES ALBUQUERQUE; ARAUJO, JOSE ROBERTO; ARIAS, VITOR; NEVES, ADRIANA COSTA; PEREIRA SILVA, MARCELO CAVENAGHI. Human Submandibular Salivary Gland Morphology Associated to Transcription and Growth Factors from Fetus to Aging. FASEB JOURNAL, v. 33, p. 2-pg., 2019-04-01. (15/03967-5)