Modulation of anti-tumor immune response by genetically modified infectious agents

• Grant number: 15/12977-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: November 01, 2015
• End date: August 31, 2019
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: João Gustavo Pessini Amarante Mendes
• Grantee: Aamir Rana
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 18/01627-0 - Modulation of anti-tumor, CD8-mediated immune response by genetically modified infectious agents, BE.EP.DR

Abstract

Cancer is one of the leading causes of death worldwide. During carcinogenesis, tumor cells acquire a series of abilities, including increased resistance to cell death and evasion of immune responses. Immunotherapy against cancer has elicited valuable clinical responses for a number of malignant diseases and was considered the breakthrough of science in 2013. Because some microorganisms exhibit preferential accumulation in the tumor micro-environment, bacterial-related therapies has been experimentally explored as novel anti-cancer strategy. The goal of this project is to study the efficiency of cancer immunotherapy triggered by different ovalbumin-expressing bacteria against syngeneic melanoma cell line expressing cytosolic or membrane-associated forms of ovalbumin.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RANA, AAMIR; DE ALMEIDA, FELIPE CAMPOS; PAICO MONTERO, HENRY A.; GONZALES CARAZAS, MARYANNE M.; BORTOLUCI, KARINA R.; SAD, SUBASH; AMARANTE-MENDES, GUSTAVO P.. RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes. FRONTIERS IN IMMUNOLOGY, v. 11, APR 9 2020. (15/12977-4, 18/01627-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

RANA, Aamir. Modulation of anti-tumor immune response by genetically modified infectious agents. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.