FUNCTIONAL ACTIVITY OF CELL MONONUCLEAR COLOSTRUM MOTHERS WITH OVERWEIGHT AND OBESITY AND THE ROLE OF AGENTS IMMUNOMODULATORS: ADIPONECTIN, LEPTIN AND MELATONIN

• Grant number: 15/01051-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: November 01, 2015
• End date: November 30, 2018
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Luiz Carlos de Abreu
• Grantee: Tassiane Cristina Morais
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Obesity is an important public health problem. It is the main characteristic of the metabolic syndrome and leads a reduced quality of life of obese individual. Need special attention in critical phases as it is in pregnancy and infancy. Pregnancy is process of the life cycle that promotes the biological vulnerability and the association with obesity increases the chance of the outcome of low birth weight and preterm newborn. There is evidence that maternal obesity promotes changes in the metabolism of the newborn that can lead to increased risk of the child developing obesity and other diseases during adulthood. The breast milk is an important modulator of the metabolism and the immune system of the child. Human milk has constituents in their composition with ability to influence the regulation of energy metabolism, such as adiponectin, leptin and melatonin. These bioactive substances also have activities on the functioning of immune cells. Literature data reported that obesity causes changes in the constituents that are present in breast milk, however it is not known how much obesity affects the action of mononuclear cells that are transmitted to the infant via colostrum. Therefore the objective of this study is evaluating the mechanisms involved in the activation of leukocytes of overweight and obesity women and the possible modulatory role of adiponectin, leptin and melatonin.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MORAIS, TASSIANE C.; DE ABREU, LUIZ C.; DE QUENTAL, OCILMA B.; PESSOA, RAFAEL S.; FUJIMORI, MAHMI; DABOIN, BLANCA E. G.; FRANCA, EDUARDO L.; HONORIO-FRANCA, ADENILDA C.. Obesity as an Inflammatory Agent Can Cause Cellular Changes in Human Milk due to the Actions of the Adipokines Leptin and Adiponectin. CELLS, v. 8, n. 6, JUN 2019. (15/01051-3, 15/19922-0)

MORAIS, TASSIANE C.; HONORIO-FRANCA, ADENILDA C.; FUJIMORI, MAHMI; DE QUENTAL, OCILMA B.; PESSOA, RAFAEL S.; FRANCA, EDUARDO L.; DE ABREU, LUIZ C.. Melatonin Action on the Activity of Phagocytes from the Colostrum of Obese Women. MEDICINA-LITHUANIA, v. 55, n. 10, OCT 2019. (15/01051-3, 15/19922-0)

DE QUENTAL, OCILMA B.; FRANCA, EDUARDO L.; HONORIO-FRANCA, ADENILDA C.; MORAIS, TASSIANE C.; DABOIN, BLANCA E. G.; BEZERRA, ITALLA M. P.; KOMNINAKIS, V, SHIRLEY; DE ABREU, LUIZ C.. Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2019, NOV 15 2019. (15/01051-3, 15/19922-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MORAIS, Tassiane Cristina. Hormones regulating energy metabolism and repercussions on the functional activity of phagocytes from colostrum of pre-gestational overweight women. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) São Paulo.