Determination of urinary biomarkers for assessment of Brazilian children exposure to endocrine disrupting chemicals: bisphenols, parabens and phthalates

• Grant number: 15/20928-3
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: March 01, 2016
• End date: December 15, 2016
• Field of knowledge: Health Sciences - Pharmacy - Toxicological Analysis
• Principal Investigator: Fernando Barbosa Júnior
• Grantee: Bruno Alves Rocha
• Supervisor: Kurunthachalam Kannan
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Institution abroad: Wadsworth Center, United States
• Associated to the scholarship: 13/23710-3 - The use of Shpol'skii spectroscopy and LC-MS/MS for determination of bisphenol A and analogues in urine samples and exposure assessment in children living in the São Paulo State, Brazil, BP.PD

Abstract

In recent years, with the increase of the use of industrial products, the world population has become more exposed to several unknown or "new" toxicants, named emerging contaminants. Among them, it is noteworthy the increase of use of a specific organic compounds, usually known as endocrine disrupting chemicals (EDCs). EDCs have become relevant topic in Science due to their potential to induce adverse effects either on human health and environment. Developed countries are already performing routinely biomonitoring assessments of EDCs on several samples of their populations, in order to obtain data that may assist researchers and public health agencies to perform studies of risk assessment, which it can prevent over exposure to these compounds by the populations as well the inadequate release to the environment. However, in development countries such Brazil, studies concerning risk assessment are still scarce. In this context, the present proposal aims the determination of three classes of EDCs: bisphenols, parabens and phthalates metabolites, in urine of children living in São Paulo State, Brazil. Finally, it is expected that the results of the present work may contribute for a better knowledge and systematic assessment of the background levels of exposure to EDCs, in Brazil.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROCHA, BRUNO A.; ASIMAKOPOULOS, ALEXANDROS G.; BARBOSA, JR., FERNANDO; KANNAN, KURUNTHACHALAM. Urinary concentrations of 25 phthalate metabolites in Brazilian children and their association with oxidative DNA damage. Science of The Total Environment, v. 586, p. 152-162, MAY 15 2017. (15/20928-3, 13/23710-3)

ROCHA, BRUNO A.; ASIMAKOPOULOS, ALEXANDROS G.; HONDA, MASATO; DA COSTA, NATTANE L.; BARBOSA, ROMMEL M.; BARBOSA, JR., FERNANDO; KANNAN, KURUNTHACHALAM. Advanced data mining approaches in the assessment of urinary concentrations of bisphenols, chlorophenols, parabens and benzophenones in Brazilian children and their association to DNA damage. Environment International, v. 116, p. 269-277, JUL 2018. (13/23710-3, 15/20928-3)