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Evaluation of the possible effects of in vitro exposure to butylparaben and di-(2-ethylhexyl) phthalate, alone or in association on steroidogenesis

Grant number: 14/09409-1
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): July 24, 2014
Effective date (End): January 23, 2015
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Wilma de Grava Kempinas
Grantee:Marina Trevizan Guerra
Supervisor abroad: Warren G. Foster
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Local de pesquisa : McMaster University, Canada  
Associated to the scholarship:13/00314-5 - Assessment of the effects of maternal exposure to butyl 4-hydroxybenzoate (butyl paraben) during gestational and lactational periods on reproductive development of wistar rats offspring, BP.PD


Endocrine Disrupting Chemicals (EDCs) are substances that may interfere with the homeostasis of natural hormones in the body. Among several classes of EDCs, important examples of these compounds are parabens and phthalates, both widely used in a variety of products and frequently found as contaminant in human tissues. Parabens are preservatives widely used in pharmaceutical products, food and beverage industries and cosmetic formulations. Phthalates are utilized in a variety of consumer's products, including personal care producs (PCPs), pharmaceuticals, medical devices, cosmetics and are the most commonly used plasticizer for polyvinyl chloride (PVC). Recent biomonitoring studies have shown that human exposure to phthalates and parabens is widespread. Furthermore, both chemicals have already been shown to induce ovarian toxicity in rodents. Although human exposure to both parabens and phthalates are well documented, the effect of these chemicals together on ovarian function are unknown. We postulate that parabens and phthalates will be more toxic in combination that alone. Therefore, the objectives of the present project are to: evaluate the effects of butylparaben and di(2-ethylhexyl) phthalate, alone and in combination on ovarian follicle development, steroidogenesis, and oocyte quality. (AU)