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Evaluation of the regulatory role of b-catenin on MMR genes modulated by H. pylori

Grant number: 15/17768-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2015
Effective date (End): November 30, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Marcelo Lima Ribeiro
Grantee:Aline Tengan Roque
Home Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil


It is known that H. pylori infection triggers a pathological progression in gastric mucosa, which eventually culminates in the development of gastric cancer. Inevitably, the infection causes an inflammatory response in the host, which generates reactive oxygen species and nitrogen, which may cause protein alterations, damage to cell membranes and oxidation DNA molecule, which are known to be important steps in the development of gastric cancer. In addition, there is evidence in the literature and obtained by our research group, showing that infection with H. pylori is directly linked to a reduction in the efficiency of DNA repair mechanisms, which would favor the accumulation of mutations and genomic instability, favoring the genesis of gastric cancer. Some recent studies show the importance of regulating via oncogenic Wnt/b-catenin in various types of cancer. However, the association between b-catenin in the DNA repair pathways are still poorly explored, especially in gastric carcinogenesis. We intend to evaluate the possible regulatory role of b-catenin in MMR genes modulated by H. pylori.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, JULIANA C.; GAMBELONI, RAFAEL Z.; ROQUE, ALINE T.; OECK, SEBASTIAN; RIBEIRO, MARCELO L. Epigenetic Mechanisms of ATM Activation after Helicobacter pylori Infection. American Journal of Pathology, v. 188, n. 2, p. 329-335, FEB 2018. Web of Science Citations: 1.

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