Isolation and characterization of cancer stem-cells from bone marrow samples of newly diagnosed patients with multiple myeloma

• Grant number: 15/23983-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): March 01, 2016
• Effective date (End): December 31, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Gisele Wally Braga Colleoni
• Grantee: Paola Marino Dantonio
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 10/17668-6 - Identification of biomarkers and possible therapeutical targets in B-cell lymphoproliferative disorders, AP.TEM

Abstract

Multiple Myeloma (MM) is the second most prevalent hematological neoplasia in the United States. It is characterized by infiltration of tumor plasma cells in the bone marrow, synthesis of monoclonal immunoglobulins and tissue damages, such as osteolytic lesions. Despite of the progress achieved in the last decades regarding the frontline treatment for MM, this malignant neoplasia remains incurable. The possible existence of cancer stem-cells of MM (MM-CSC) explains the disease's relapse and resistance to treatments. This way, studies aiming a better characterization and comprehension of MM-CSC, focusing on finding potential therapeutic targets, are essential for developing new medications capable of promoting better survival and quality of life to the individuals affected by this disease. Thus, our intention is to identify and isolate these cancer stem-cells, which might be a potential therapeutic target for the disease.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARBOSA, REBECCA S. S.; DANTONIO, PAOLA M.; GUIMARAES, TAIS; DE OLIVEIRA, MARIANA B.; FOOK ALVES, VERUSKA L.; SANDES, ALEX FREIRE; FERNANDO, RODRIGO CARLINI; COLLEONI, GISELE W. B.. Sequential combination of bortezomib and WEE1 inhibitor, MK-1775, induced apoptosis in multiple myeloma cell lines. Biochemical and Biophysical Research Communications, v. 519, n. 3, p. 597-604, NOV 12 2019. (10/17668-6, 17/21801-2, 15/23983-5, 17/17101-5)

DE OLIVEIRA, MARIANA BLEKER; DANTONIO, PAOLA MARINO; ALVES, VERUSKA LIA FOOK; FERNANDO, RODRIGO CARLINI; TEIXEIRA, DANIELA; BASSO, ALEXANDRE; YAMAMOTO, MIHOKO; COLLEONI, GISELE W. B.. Multiple Myeloma Cancer Stem Cells: Immunophenotypic and Functional Characterization, Gene Expression Profiling and Therapeutic Targets. Blood, v. 128, n. 22, p. 5-pg., 2016-12-02. (15/23983-5, 10/17668-6)