Influence of the DTPa vaccination in pregnant women in the type of immunological response against Bordetella pertussis in children

• Grant number: 15/19726-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2016
• End date: February 28, 2018
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Cyro Alves de Brito
• Grantee: Carolina Argondizo Correia
• Host Institution: Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The whooping cough is an acute infectious and contagious disease from the respiratory tract, caused by Bordetella pertussis bacteria. Its attack rate reaches 90% among non-immunized people, thus contributing to child mortality around the world. The vaccination introduction was fundamental for the fall of over 95% of the whooping cough incidence, but, in recent years, a rise in global cases has been seen.A strategy aimed to control the disease's re-emergence is the offer of vaccines to pregnant women, since the pregnancy's third trimester. The objective is to induce high antibodies titres in the foetus, resulting in the protection of the newborn in the first months of life, i.e. before the regular vaccination scheme is complete. In the end of 2014, the Ministry of Health officialised the decision to include the new vaccine in the National Vaccination Calendar, which will be available throughout the country in the next months.Beside the strategy of vaccinating pregnant women is already used in several countries, little is known about its efficacy, effectiveness and interaction with the later child vaccination. Maternal antibodies can help to protect newborns from the infection caused by B. pertussis, but can also neutralize the child vaccination, lowering the vaccine efficiency. Besides, the maternal immunization during pregnancy can cause the transference of antigens and cytokines to the foetus, which can induce a deviation in the response pattern or even immunological tolerance of the newborn. These aspects are particularly important and should be investigated when new maternal vaccination programs are being implemented.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ARGONDIZO-CORREIA, CAROLINA; SOUSA RODRIGUES, ANA KELLY; DE BRITO, CYRO ALVES. Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies. JOURNAL OF IMMUNOLOGY RESEARCH, 2019. (15/19726-7)

ARGONDIZO-CORREIA, CAROLINA; SOUSA RODRIGUES, ANA KELLY; DE BRITO, CYRO ALVES. Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2019, p. 10-pg., 2019-01-01. (15/19726-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CORREIA, Carolina Argondizo. Influence of pregnant women\'s Tdap vaccination in the child\'s immunological response profile against Bordetella pertussis. 2018. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Medicina Tropical de São Paulo (IMT) São Paulo.