Modulation of expression of S6Ks in the central nervous system and its effects in obesity

• Grant number: 15/24475-3
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: April 01, 2016
• End date: August 31, 2019
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Fernando Moreira Simabuco
• Grantee: Mariana Rosolen Tavares
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
• Associated research grant: 12/13558-7 - Molecular characterization of S6Ks in obesity and its associated diseases, AP.JP
• Associated scholarship(s): 18/07018-6 - Role of hypothalamic S6Ks in metabolic regulation, BE.EP.DD

Abstract

Obesity has been considered a worldwide epidemic. In Brazil, more than half of the population is overweight and obesity values continue to rise. World Health Organization (WHO) data are categorical to assert that obesity is related to a number of diseases, including: diabetes mellitus type II, cardiovascular disease, Cerebrovascular Accident (CVA), dyslipidemia, osteoarthritis and some types of cancer. Thus, there is currently great demand for a better understanding of the biochemical and metabolic processes related to obesity. The signaling pathway of mTOR protein has been associated with the control of energy balance in the body, working as a sensor of the amount of nutrients available and signaling to the expenditure of the stored energy. The present research project aims to study the role of S6Ks, known effectors of mTOR, in the Central Nervous System (CNS) and its consequences for energy homeostasis. For that, protein expression of the different S6Ks isoforms will be modulated in the CNS to characterize their roles in CNS, as well as their peripheral effects in the body. It is clear the demand to fully investigate the pathway of mTOR/S6Ks due to its importance in metabolic changes, obesity and associated pathologies. Only with complete understanding of the functions of S6Ks, effectors of mTOR pathway, it will be possible to develop safe and effective treatments for those pathologies. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TAVARES, MARIANA ROSOLEN; LEMES, SIMONE FERREIRA; DE FANTE, THAIS; DE MIERA, CRISTINA SAENZ; BETIM PAVAN, ISADORA CAROLINA; NEVES BEZERRA, ROSANGELA MARIA; PRADA, PATRICIA OLIVEIRA; TORSONI, MARCIO ALBERTO; ELIAS, CAROL FUZETI; SIMABUCO, FERNANDO MOREIRA. Modulation of hypothalamic S6K1 and S6K2 alters feeding behavior and systemic glucose metabolism. Journal of Endocrinology, v. 244, n. 1, p. 71-82, JAN 2020. (12/13558-7, 13/22696-7, 18/14818-9, 18/07018-6, 15/24475-3, 16/06457-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

TAVARES, Mariana Rosolen. Modulation of S6Ks expression in the nervous central system and effects in obesity. 2019. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.