Mortality rate of AIDS patients: comparison between the ages before and after potent antiretroviral therapy

• Grant number: 16/01335-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2016
• End date: May 31, 2017
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Lenice Do Rosário de Souza
• Grantee: Elisa Carmo de Pina
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

AIDS is the disease characterized by progressive and significant depletion of the immune system. The period of development of AIDS as well as the response to the various antiretroviral schemes. Several studies have been done in Brazil and worldwide over the years concerning the natural history of HIV/AIDS, the survival of patients with or without treatment and the use of different antiretroviral regimens since the release of the first drug for clinical use, the zidovudine. Thus, the aim of this study is delineate the profile of the patients with HIV infection or AIDS seen in the Infectious Diseases Service of FMB-UNESP that evaluated to death. We will assess patients' clinical, immunological and virological evolutions from 1985 until 2014 and it will be analyzed the rates of annual mortality associated with AIDS and survival related with the antiretroviral regimen used. Therefore 228 medical records will be analyzed.