EFFECTS OF TREATMENT WITH HYDROXYUREA IN THE ORAL CAVITY OF PEDIATRIC PATIENTS WITH SICKLE CELL ANEMIA

• Grant number: 16/09670-7
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: September 01, 2016
• End date: December 31, 2016
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Cristiane Yumi Koga Ito
• Grantee: Marcia Hiromi Tanaka
• Supervisor: Bruce Jay Paster
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil
• Institution abroad: Forsyth Institute, United States
• Associated to the scholarship: 14/13469-0 - Effects of treatment with hydroxyurea in the oral cavity of pediatric patients with sickle cell anemia, BP.PD

Abstract

The purpose of this study will be to investigate the effects of hydroxyurea (HU) used in the treatment of sickle cell anemia (SCA) on the oral microbioma. Forty children aged 6 to 14 years divided into 4 groups: G1 (10 patients with SCA at the beginning of treatment with HU), G2 (10 patients with SCA and under treatment with HU for 3 months), G3 (10 patients with SCA and under treatment with HU for 6 months) and G4 (10 systemically healthy children, paired-control). This will be a longitudinal study and the bacterial oral microflora will be also analyzed by Human Oral Microbe Identification using Next Generation Sequencing (HOMINGS) in children under HU therapy and control. The results will be analyzed by appropriate statistical tests (±=0.05).