Wound healing therapy with hBMSC-TERT in experimental model of Diabetes Mellitus

• Grant number: 16/07423-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2016
• End date: July 31, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Ângela Merice de Oliveira Leal
• Grantee: Giovanni Pavanello Brandão
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

The actual global epidemiological picture presents technical and economic issues that challenges the overcome of chronic diseases. Chronics ulcerations in diabetic patients are a good example of it: the impaired healing, the lack of painful sensibility and constant trauma create a cycle in which the scarcity of resources for appropriate treatment corroborates the worsening of the wound. The project aims to evaluate the therapeutic possibilities of hBMSC-TERT cells in experimental Diabetes models. Winstar rats with streptozotocin induced Diabetes will be submitted to a lesion procedure for posterior hBMSC-TERT multiple applications. Thus, TGFbeta, TNFalfa, VEGF, NFkB levels will be measured as predictors of wound healing process. The resulting data will be compared among experimental groups and statistically evaluated. The expectations are the improvement of wound treated with stem cells as well as the balance of the cytokines. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LUNA, G. L. FLORES; OEHLMEYER, T. L.; BRANDAO, G.; BRASSOLATTI, P.; TOSTA, J.; GOTO, L. S.; DE AVO, L.; LEAL, A. M. DE OLIVEIRA. Use of human bone marrow mesenchymal stem cells immortalized by the expression of telomerase in wound healing in diabetic rats. Brazilian Journal of Medical and Biological Research, v. 54, n. 11, 2021. (16/07423-2)