Acute hemodynamic and metabolic response to self-regulated high-intensity interval exercise in type 2 diabetic patients

• Grant number: 16/08205-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2016
• End date: July 31, 2017
• Field of knowledge: Biological Sciences - Physiology - Physiology of Effort
• Principal Investigator: Emmanuel Gomes Ciolac
• Grantee: Bianca Fernandes
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil

Abstract

Type 2 diabetes mellitus (T2DM) is highly prevalent disease with increasingly incidence worldwide. Physical exercise promotion is one of the main global goals of innumerous health and medical societies for preventing and managing non-communicable chronic diseases, and is recommended for treatment of T2DM. There is an emerging evidence indicating that engaging in high intensity exercise may promote additional health-related benefits than performing only moderate intensity exercise, including improvements in several variables related to T2DM physiopathology. On the other hand, the exercise targets implementation, completion and compliance remain difficult (if not impossible) to be achieved, with poor exercise compliance showing to be its Achilles' heel. Self-regulated exercise programs have a cost-effective appealing, and may have implications for overcoming many barriers related to poor exercise compliance. However, little is known about the feasibility and effects of self-regulated high-intensity exercise programs in T2DM. Purpose: To investigate the acute hemodynamic and metabolic response to self-regulated high-intensity interval exercise in T2DM patients. Methods: 34 sedentary T2DM patients (aged 30 to 65 years), of both gender, will be randomly assigned to perform 4 interventions (2 to 5 days of interval between interventions): 1) 25 min of high-intensity interval training (HIT) session prescribed and self-regulated by rating of perceived exertion (HIT-RPE); 2) 25 min of HIT session prescribed and regulated by the heart rate (HR) response to maximal graded exercise testing (HIT-HR); 3) 25 min of continuous moderate intensity exercise session prescribed and regulated by the HR response to maximal graded exercise testing (CME-HR); and 4) 25 min no exercise control session (CON). Capillary glucose, blood pressure (BP) arterial stiffness, endothelial function and heart rate variability will be analyzed before, immediately after, 30 min after 1 h and after each intervention. Ambulatory BP and HR will also be analyzed for 24h, with the monitoring beginning 1 h after the interventions.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NGOMANE, AWASSI YOPHIWA; FERNANDES, BIANCA; GUIMARAES, GUILHERME VEIGA; CIOLAC, EMMANUEL GOMES. Hypotensive Effect of Heated Water-based Exercise in Older Individuals with Hypertension. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 40, n. 4, p. 283-291, APR 2019. (15/09259-2, 16/08205-9)

FERNANDES, BIANCA; BARBIERI, FABIO AUGUSTO; ARTHUSO, FERNANDA ZANE; SILVA, FABIANA ARAUJO; MORETTO, GABRIEL FELIPE; ITIKAWA IMAIZUMI, LUIS FELIPE; NGOMANE, AWASSI YOPHIWA; GUIMARAES, GUILHERME VEIGA; CIOLAC, EMMANUEL GOMES. High-Intensity Interval Versus Moderate-Intensity Continuous Training in Individuals With Parkinson's Disease: Hemodynamic and Functional Adaptation. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. 17, n. 1, p. 85-91, JAN 2020. (15/09259-2, 16/08205-9)

VIANA, ARIANE APARECIDA; FERNANDES, BIANCA; ALVAREZ, CRISTIAN; GUIMARAES, GUILHERME VEIGA; CIOLAC, EMMANUEL GOMES. Prescribing high-intensity interval exercise by RPE in individuals with type 2 diabetes: metabolic and hemodynamic responses. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, v. 44, n. 4, p. 348-356, APR 2019. (16/08205-9)