Use of Canabidiol in the consolidation of aversive memories in victims of PTSD.

• Grant number: 16/01801-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2016
• End date: February 13, 2019
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Antonio Waldo Zuardi
• Grantee: Lívia Maria Bolsoni
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Cannabidiol (CBD), a compound of the cannabis sativa plant, has been investigated in animal and human studies. These studies corroborate the hypothesis of the anxiolytic effect of this compound, as well as its interference in the reconsolidation and extinction of aversive memories. It is to evaluate whether the administration of 300 mg of CBD before remembrance of the traumatic event attenuates the anxiety symptoms produced by this recall in people diagnosed with PTSD. A total of 40 male and female individuals aged 18-60 years who are diagnosed with PTSD according to SCID-V and who agree to participate in the study will be screened. All participants will be subject to the inclusion and exclusion criteria and, if they fit the study, will be scheduling one day to start the tests. On that day (Day 1), BMI will be calculated and applied to PCL-5 and then randomly divided into two groups to additionally receive CBD (300mg) or placebo in a double-blind procedure. Also on that day, tests will be performed to evaluate the physiological correlates (PA, FC and CS) and psychological (IDATE-E and VAMS). After that, a reminder will be given of the aversive event, which includes recording the traumatic event report, followed by the request to imagine the trauma for thirty seconds in the most vivid way possible. After the test, the physiological and psychological correlates will be reevaluated. Seven days later (Day 2), participants in a laboratory setting should receive CBD or placebo. After 2.5 h, the physiological and psychological correlates will be checked and participants will be reexposed to the recall test. New measurements will be made. After 7 days (Day 3), participants will be submitted to the same procedure as Day 2, but without pharmacological intervention. The results of this project may contribute to a better understanding of the potential therapeutic effects of CBD and provide data for new clinical applications of the drug

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LOPES, SAMUEL; HALLAK, JAIME EDUARDO CECILIO; MACHADO DE SOUSA, JOAO PAULO; OSORIO, FLAVIA DE LIMA. Adverse childhood experiences and chronic lung diseases in adulthood: a systematic review and meta-analysis. EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY, v. 11, n. 1, DEC 31 2020. (16/01801-5)

BOLSONI, LIVIA MARIA; ZUARDI, ANTONIO WALDO. Pharmacological interventions during the process of reconsolidation of aversive memories: A systematic review. NEUROBIOLOGY OF STRESS, v. 11, NOV 2019. (16/01801-5)

PEREIRA-LIMA, KARINA; MATA, DOUGLAS A.; LOUREIRO, SONIA R.; CRIPPA, JOSE A.; BOLSONI, LIVIA M.; SEN, SRIJAN. Association Between Physician Depressive Symptoms and Medical Errors A Systematic Review and Meta-analysis. JAMA NETWORK OPEN, v. 2, n. 11, NOV 2019. (16/01801-5, 16/13410-0, 18/21480-4)

LOPES, SAMUEL; HALLAK, JAIME EDUARDO CECILIO; MACHADO DE SOUSA, JOAO PAULO; OSORIO, FLAVIA DE LIMA. Adverse childhood experiences and chronic lung diseases in adulthood: a systematic review and meta-analysis. EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY, v. 11, n. 1, p. 9-pg., 2020-01-01. (16/01801-5)

BOLSONI, LIVIA MARIA; CRIPPA, JOSE ALEXANDRE S.; CECILIO HALLAK, JAIME EDUARDO; GUIMARAES, FRANCISCO SILVEIRA; ZUARDI, ANTONIO WALDO. The anxiolytic effect of cannabidiol depends on the nature of the trauma when patients with post-traumatic stress disorder recall their trigger event. Revista Brasileira de Psiquiatria, v. 44, n. 3, p. 10-pg., 2022-05-01. (20/05416-4, 16/01801-5, 08/09009-2)

PEREIRA-LIMA, KARINA; LOUREIRO, SONIA REGINA; BOLSONI, LIVIA MARIA; APOLINARIO DA SILVA, THIAGO DORNELA; OSORIO, FLAVIA LIMA. Psychometric properties and diagnostic utility of a Brazilian version of the PCL-5 (complete and abbreviated versions). EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY, v. 10, n. 1, JAN 1 2019. (14/06972-7, 16/01801-5)

BOLSONI, L.; ZUARDI, A.. Intervention for aversive memory reconsolidation - A critical review. EUROPEAN PSYCHIATRY, v. 48, p. 1-pg., 2018-03-01. (16/01801-5)

PEREIRA-LIMA, KARINA; LOUREIRO, SONIA REGINA; BOLSONI, LIVIA MARIA; APOLINARIO DA SILVA, THIAGO DORNELA; OSORIO, FLAVIA LIMA. Psychometric properties and diagnostic utility of a Brazilian version of the PCL-5 (complete and abbreviated versions). EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY, v. 10, n. 1, p. 9-pg., 2019-01-01. (14/06972-7, 16/01801-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BOLSONI, Lívia Maria. Effects of Cannabidiol on anxiety induced by recall of traumatic event in patients diagnosed with posttraumatic stress disorder. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.