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Evaluation of the mechanism of action of ruthenium complexes containing bioactive natural products

Grant number: 16/18530-4
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): December 01, 2016
Effective date (End): August 31, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Alzir Azevedo Batista
Grantee:Katia Mara de Oliveira
Supervisor: Nicholas Farrell
Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Research place: Virginia Commonwealth University (VCU), United States  
Associated to the scholarship:14/04147-9 - Evaluation of anticancer properties of ruthenium(II)complexes containing lapachol and lawsone bioligands, BP.DR


Cancer is the second leading cause of death worldwide and, the forms of treatment of this disease has some limitations, by making necessary to develop new compounds that may be effective against this disease. The ruthenium complexes has been quite promising, showing metastatic properties. Therefore, in this project will be studied ruthenium complexes containing the lapachol as ligand, which have shown interesting properties front the cell line of breast MDA-MB-231. The complexes of the following general formula [Ru(L)(dppe)(bipy)]PF6 and [Ru(L)(dppm)2]PF6, where L = lapachol, dppe = 1,2'-bis(diphenylphosphine)ethane, dppm = bis(diphenylphosphino)methane and bipy = 2,2'-bipyridine, showed able to induce the migration of MDA-MB-231 cells and induce cell death by apoptosis. The objective of this project is to investigate the mechanism of action of ruthenium complexes, seeking information about the entry of the complexes into the cell, specifically in the nucleolus and assess their effects. From the chemical and biological results it is expected that a mechanism of action for the ruthenium complexes can be elucidated as well as a relationship between structure and activity.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, KATIA M.; PETERSON, ERICA J.; CARROCCIA, MURILO C.; COMINETTI, MARCIA R.; DEFLON, VICTOR M.; FARRELL, NICHOLAS P.; BATISTA, ALZIR A.; CORREA, RODRIGO S.. Ru(II)-Naphthoquinone complexes with high selectivity for triple-negative breast cancer. DALTON TRANSACTIONS, v. 49, n. 45, p. 16193-16203, . (14/04147-9, 16/18530-4, 16/16312-0)

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