Cancer is the second leading cause of death worldwide and, the forms of treatment of this disease has some limitations, by making necessary to develop new compounds that may be effective against this disease. The ruthenium complexes has been quite promising, showing metastatic properties. Therefore, in this project will be studied ruthenium complexes containing the lapachol as ligand, which have shown interesting properties front the cell line of breast MDA-MB-231. The complexes of the following general formula [Ru(L)(dppe)(bipy)]PF6 and [Ru(L)(dppm)2]PF6, where L = lapachol, dppe = 1,2'-bis(diphenylphosphine)ethane, dppm = bis(diphenylphosphino)methane and bipy = 2,2'-bipyridine, showed able to induce the migration of MDA-MB-231 cells and induce cell death by apoptosis. The objective of this project is to investigate the mechanism of action of ruthenium complexes, seeking information about the entry of the complexes into the cell, specifically in the nucleolus and assess their effects. From the chemical and biological results it is expected that a mechanism of action for the ruthenium complexes can be elucidated as well as a relationship between structure and activity.
News published in Agência FAPESP Newsletter about the scholarship: