Development of patches containing the association of artemether-lumefantrine for the treatment of malaria caused by Plasmodium falciparum

• Grant number: 16/18384-8
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: February 01, 2017
• End date: November 30, 2017
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Mary Ann Foglio
• Grantee: Fabiana Volpe Zanutto
• Supervisor: Ryan Francis Donnelly
• Host Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil
• Institution abroad: Queen's University Belfast, Northern Ireland
• Associated to the scholarship: 14/16008-3 - Development of patches containing the association of artemether - lumefantrine for the treatment of malaria caused by Plasmodium falciparum, BP.DR

Abstract

Malaria is one of the most important parasitoids worldwide, affecting approximately 300 million people each year. This is an acute feverish infectious disease transmitted by Anopheles genus vector, whose agents are the Plasmodium sp. Malaria has a conventional therapy, which is often hampered, because the patients do not undergo the medical treatment properly, thus favoring Plasmodium resistance. Considering the small quantity of innovative antimalarials medicine approved in the last decades, the pursuit of more effective and less toxic antimalarial drugs and the design of pharmaceutical systems based on microneedle arrays (MNs) could be considered as the main processes of fighting this disease. Thus, the aim of this work is the development of a transdermal patch to treat malaria, in order to increase the patient's adhesion to therapy and to help reduce mortality rates due to these parasitoids. Therefore MN will be developed since they are minimally invasive devices that painlessly by-pass the skin's stratum corneum, which is the principal barrier to topically-applied drugs. The arrays will be analyzed by scanning electron microscopy, dimension uniformity, tensile strength, percentage elongation and young's. After development and characterization, dissolution study and Franz cells measurements will be taken. The quantification by active compounds will be analyzed by HPLC/MS. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VOLPE-ZANUTTO, FABIANA; FONSECA-SANTOS, BRUNO; MCKENNA, PETER E.; PAREDES, ALEJANDRO J.; DAVILA, JOSE LUIS; MCCRUDDEN, MAELIOSA T. C.; PEREIRA TANGERINA, MARCELO MARUCCI; FIGUEIREDO, MARIANA CECCHETO; VILEGAS, WAGNER; BRISIBE, ANDI; et al. Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs artemether-lumefantrine. Biomedical Materials, v. 16, n. 6, NOV 1 2021. (16/18384-8, 14/16008-3)

ZANUTTO, FABIANA VOLPE; MCALISTER, EMMA; PEREIRA TANGERINA, MARCELO MARUCCI; FONSECA-SANTOS, BRUNO; COSTA SALLES, TAIS HELENA; OLIVEIRA SOUZA, ILZA MARIA; BRISIBE, ANDI; VILEGAS, WAGNER; CHORILLI, MARLUS; D'AVILA, MARCOS AKIRA; et al. Semisynthetic Derivative of Artemisia annua-Loaded Transdermal Bioadhesive for the Treatment of Uncomplicated Malaria Caused by Plasmodium falciparum in Children. Journal of Pharmaceutical Sciences, v. 108, n. 3, p. 1177-1188, MAR 2019. (16/18384-8, 14/16008-3)

MANCUSO, I, R.; FOGLIO, M. A.; SAAD, S. T. OLALLA. Artemisinin-type drugs for the treatment of hematological malignancies. Cancer Chemotherapy and Pharmacology, v. 87, n. 1, NOV 2020. (17/21801-2, 16/18384-8, 14/16008-3)

VOLPE-ZANUTTO, FABIANA; FERREIRA, LETICIA TIBURCIO; PERMANA, ANDI DIAN; KIRKBY, MELISSA; PAREDES, ALEJANDRO J.; VORA, LALITKUMAR K.; BONFANTI, AMANDA P.; CHARLIE-SILVA, IVES; RAPOSO, CATARINA; FIGUEIREDO, MARIANA C.; et al. Artemether and lumefantrine dissolving microneedle patches with improved pharmacokinetic performance and antimalarial efficacy in mice infected with Plasmodium yoelii. JOURNAL OF CONTROLLED RELEASE, v. 333, p. 298-315, MAY 10 2021. (19/02171-3, 16/18384-8, 14/16008-3, 17/18611-7)