Biodegradable scaffolds have shown great potential to aid in tissue engineering. The combination of factors such as the distribution of nanofibers and the incorporation of nanoparticles, which can guide and accelerate bone cells, can optimize the process of bone repair. In this study will be produced scaffolds PBAT embedded with carbon nanotubes nanoparticles (CNTs) and nanohidroxiapatita (nHA), to orthopedic and dental applicability. The scaffolds will be produced by electrospinning technique and divided into three groups according to their composition: a) PBAT (control); b) PBAT incorporated with nHA; c)PBAT embedded with nHA/CNTs. Sixty male adult rats will be used on this study. First of allit will be done 3 centimeters drillings in right and left tibias with serial drills and plenty irrigation. The animals will be separated in 3 groups according to the left tibia filling bone defect: a) PBAT, b) PBAT incorporated with nHA, and c) PBAT incorporated withnHA/CNTs. On the other hand, right tibia critical defects will be filled with clot (control).Each group will be subdivided according to euthanasia period of 2 and 6 weeks (n=10 byperiod). On each five animals from each period, the bone repair area will be assessed through histologic analysis and histomorphometic, meanwhile the other 5 animals the bonerepair area will be submitted to flexion resistance test. The data shall be statistically analyzed, initially through the normality test in order to apply an adequate statistic test. The level of significance adopted will be the conventional value of 5%.
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