Effects of concurrent training on muscle satellite cells and myofibrillar protein synthesis

• Grant number: 15/19756-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2016
• End date: December 14, 2020
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Carlos Ugrinowitsch
• Grantee: Miguel Soares Conceição
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 17/18780-3 - EFFECTS OF CONCURRENT TRAINING ON MUSCLE SATELLITE CELLS AND MYOFIBRILLAR PROTEIN SYNTHESIS, BE.EP.PD

Abstract

Can Satellite Cells (SC) and Myofibrilar Protein Synthesis (MPS) explain the lower muscle gains after Concurrent Training (CT) compared to Resistance Training (RT) alonere. Main: to compare muscle fiber hypertrophy, number of SC and myonuclei and the MPS after 16 weeks of CT and RT. Methods: 20 young male subjects will be allocated in one of the following groups: concurrent training (CT, n=10) or resistance training (RT, n=10). The RT group will perform Leg press, leg extension and leg Curl, 5x8-12 maximum repetitions with 90s of rest, 3x per week. The CT group will perform the same RT protocol followed by a running exercise, 5 sprints of 4 min at an intensity of 85% of VO2máx with 3 min of rest between sets. The subjects will undergo for 3 muscle samples, 2 blood samples, 6 salive samples before and after the first and last training session and 1 muscle strength test and maximum oxygen intake test (VO2máx) before and after experimental period. As CS analysis by immunofluorescence were done in my PhD study, thus the main challenge in the present proposal will be determine the colocalization of gene that can activate SC. The rate of MPS by deuterated water (²H2O) is being performed in one study from our lab headed for Prof. Carlos Ugrinowitsch (FAPESP 2014/19594-0) with collaboration of Prof Stuart Phillips from Mac Master University, Canada. Thus, I believe that I have necessary conditions to understand the physiological mechanisms that can clarify why the muscle hypertrophy is smaller after CT compared RT alone. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CONCEICAO, MIGUEL S.; DERCHAIN, SOPHIE; VECHIN, FELIPE CASSARO; TELLES, GUILHERME; MAGINADOR, GUILHERME FIORI; SARIAN, LUIS OTAVIO; LIBARDI, CLEITON AUGUSTO; UGRINOWITSCH, CARLOS. Maintenance of Muscle Mass and Cardiorespiratory Fitness to Cancer Patients During COVID-19 Era and After SARS-CoV-2 Vaccine. FRONTIERS IN PHYSIOLOGY, v. 12, JUN 25 2021. (15/19756-3)

CONCEICAO, MIGUEL S.; JUNIOR, EDSON M. M.; TELLES, GUILHERME D.; LIBARDI, CLEITON A.; CASTRO, ALEX; ANDRADE, ANDRE L. L.; BRUM, PATRICIA C.; URIAS, URSULA; KURAUTI, MIRIAN AYUMI; COSTA JUNIOR, JOSE MARIA; et al. Augmented Anabolic Responses after 8-wk Cycling with Blood Flow Restriction. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 51, n. 1, p. 84-93, JAN 2019. (14/00985-0, 15/19756-3)

MAGINADOR, GUILHERME; LIXANDRAO, MANOEL E.; BORTOLOZO, HENRIQUE I.; VECHIN, FELIPE C.; SARIAN, LUIS O.; DERCHAIN, SOPHIE; TELLES, GUILHERME D.; ZOPF, EVA; UGRINOWITSCH, CARLOS; CONCEICAO, MIGUEL S.. Aerobic Exercise-Induced Changes in Cardiorespiratory Fitness in Breast Cancer Patients Receiving Chemotherapy: A Systematic Review and Meta-Analysis. CANCERS, v. 12, n. 8, AUG 2020. (15/19756-3)

CONCEICAO, MIGUEL S.; VECHIN, FELIPE C.; LIXANDRAO, MANOEL; DAMAS, FELIPE; LIBARDI, CLEITON A.; TRICOLI, VALMOR; ROSCHEL, HAMILTON; CAMERA, DONNY; UGRINOWITSCH, CARLOS. Muscle Fiber Hypertrophy and Myonuclei Addition: A Systematic Review and Meta-analysis. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 50, n. 7, p. 1385-1393, JUL 2018. (16/09759-8, 15/19756-3)

BORTOLOZO, HENRIQUE IMS; DERCHAIN, SOPHIE; VECHIN, FELIPE C.; MAGINADOR, GUILHERME F.; SANTOS, IZABELLA SILVA; TORRESAN, RENATO; SILVA DOS SANTOS, PRISCILLA DE NAZARE; SARIAN, LUIS OTAVIO; CONCEICAO, MIGUEL S.. Aerobic Fitness is a Predictor of Body Composition in Women With Breast Cancer at Diagnosis. CLINICAL BREAST CANCER, v. 21, n. 3, p. E245-E251, JUN 2021. (19/23890-8, 15/19756-3)

CONCEICAO, MIGUEL S.; UGRINOWITSCH, CARLOS. Exercise with blood flow restriction: an effective alternative for the non-pharmaceutical treatment for muscle wasting. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v. 10, n. 2, p. 6-pg., 2019-04-01. (16/09759-8, 15/19756-3)

TELLES, GUILHERME DEFANTE; LIXANDRAO, MANOEL; CONCEICAO, MIGUEL. Effects of combined exercise training in older adults: a potential relationship between muscle fibre satellite cell function and capillarization. JOURNAL OF PHYSIOLOGY-LONDON, v. 597, n. 8, p. 2-pg., 2019-04-15. (17/01297-8, 18/16513-0, 16/22635-6, 15/19756-3)