Effect of different alcoholic beverages consumption (fermented, distilled and wine) in semen parameters, hormonal and sperm function

• Grant number: 16/06812-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2016
• End date: October 31, 2017
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Jorge Hallak
• Grantee: Victória dos Santos Coutinho
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

In according to the World Health Organization (WHO), alcohol consumption is one of the top 5 causes of death, disability and disease in the world, coming to cause 3.3 million deaths a year. Despite the excessive consumption of alcohol is proven harmful to health, the relationship between the consumption of different doses (especially moderate) alcohol and change the parameters that determine the male fertile potential has not yet been elucidated. Our aim is to correlate the alcohol consumption, considering the characteristics of alcoholic beverages (fermented, distilled or wine) and the level of consumption with parameters that define the male fertile potential, by investigation of seminal parameters, sperm functional profile and hormonal profile. A retrospective study will be performed by examining electronic records of infertile patients between the years 2000 and 2016, reporting alcohol consumption; and prospective, performing sperm function tests on 100 semen samples of patients of the health service. Patients are divided into groups according to type and amount of consumed beverage and compared to a control group (fertile patients) and a group of infertile patients who do not drink alcohol. The samples will be categorized according to strength of consumption and type of alcohol, allowing the factor analysis of the data and the interaction between parameters. The data will be evaluated to see if present homogeneity of variances and normality of residuals. The Pearson test is used if the variables have normal distribution. If the variables did not present normal distribution, the Spearman Users ranked test will be used. For the entire study will be adopted an alpha of 5%. (AU)