In vitro firocoxib antitumor activity in canine mammary carcinoma cells and its metastasis

• Grant number: 16/21474-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2017
• End date: December 31, 2017
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Carlos Eduardo Fonseca Alves
• Grantee: Andressa Brandi
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The mammary gland tumors (MGT) are common in non-castrated female dogs and in approximately 50% of cases; the malignant tumors show aggressive histological subtypes. Besides the high incidence, canine MGT are a comparative model to breast cancer in women and both species can benefit with comparative studies. In women, several studies had shown the importance of the COX-2 selective inhibitors use in tumor prevention and metastases control. In bitches, some studies have associated COX-2 expression in invasive and metastatic MGT. However, these studies COX-2 expression by immunohistochemistry. Therefore, these studies did not look at the identification of the mechanisms involved in the COX-2 overexpression with negative prognostic factors. Due to importance of MGT in female dogs, this research aims to evaluate the antitumor response of the COX-2 inhibitor Firocoxib in primary canine mammary gland carcinoma cells and its metastases. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FRANZONI, MAYARA SIMAO; BRANDI, ANDRESSA; DE OLIVEIRA MATOS PRADO, JANE KARLLA; ELIAS, FABIANA; DALMOLIN, FABFOLA; LAINETTI, PATRICIA DE FARIA; MANGINI PRADO, MARIA CAROLINA; LEIS-FILHO, ANTONIO FERNANDO; FONSECA-ALVES, CARLOS EDUARDO. Tumor-infiltrating CD4(+) and CD8(+) lymphocytes and macrophages are associated with prognostic factors in triple-negative canine mammary complex type carcinoma. Research in Veterinary Science, v. 126, p. 29-36, OCT 2019. (16/21474-9)

DE FARIA LAINETTI, PATRICIA; BRANDI, ANDRESSA; LEIS FILHO, ANTONIO FERNANDO; PRADO, MARIA CAROLINA MANGINI; KOBAYASHI, PRISCILA EMIKO; LAUFER-AMORIM, RENEE; FONSECA-ALVES, CARLOS EDUARDO. Establishment and Characterization of Canine Mammary Gland Carcinoma Cell Lines With Vasculogenic Mimicry Ability in vitro and in vivo. FRONTIERS IN VETERINARY SCIENCE, v. 7, OCT 27 2020. (16/21474-9)