| Grant number: | 16/21474-9 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | January 01, 2017 |
| End date: | December 31, 2017 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery |
| Principal Investigator: | Carlos Eduardo Fonseca Alves |
| Grantee: | Andressa Brandi |
| Host Institution: | Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
Abstract The mammary gland tumors (MGT) are common in non-castrated female dogs and in approximately 50% of cases; the malignant tumors show aggressive histological subtypes. Besides the high incidence, canine MGT are a comparative model to breast cancer in women and both species can benefit with comparative studies. In women, several studies had shown the importance of the COX-2 selective inhibitors use in tumor prevention and metastases control. In bitches, some studies have associated COX-2 expression in invasive and metastatic MGT. However, these studies COX-2 expression by immunohistochemistry. Therefore, these studies did not look at the identification of the mechanisms involved in the COX-2 overexpression with negative prognostic factors. Due to importance of MGT in female dogs, this research aims to evaluate the antitumor response of the COX-2 inhibitor Firocoxib in primary canine mammary gland carcinoma cells and its metastases. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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