Immune thrombocytopenia purpura: morphological and clinical aspects in patients with bone marrow biopsy

• Grant number: 16/19603-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2017
• End date: January 31, 2018
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Cristiano Claudino Oliveira
• Grantee: Rafael Guimarães Kanda
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Immune-mediated thrombocytopenia purpura (ITP) is an important autoimmune disorder characterized by thrombocytopenia induced by the action of autoantibodies promoters of platelet destruction and decreased megakaryocytopoiesis. The use of biopsy/bone marrow aspirate is recommended for selected cases such as the elderly, or with atypical symptoms that arise differential neoplastic diagnostic possibilities. A classic and unique morphological pattern to the bone marrow in ITP does not exist. The association between different morphological findings and clinical-prognostic parameters has been little explored in the literature, and is therefore a suitable theme to new approaches that can provide aids able to justify the need to use the bone marrow biopsy/aspirate in these patients. (AU)