Effect of dual specificity phosphatases modulation and sensitization to gemcitabine

• Grant number: 16/23013-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: December 01, 2016
• End date: June 30, 2018
• Field of knowledge: Biological Sciences - Genetics
• Principal Investigator: Vanessa da Silva Silveira
• Grantee: Verena Silva Santos
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 15/10694-5 - Dual specificity phosphatases activity on map kinases signaling regulation: impact on pancreatic ductal adenocarcinoma metabolic reprogramming, AP.JP

Abstract

Given the difficulty to find specific drugs which can treat pancreatic ductal adenocarcinoma (PDAC) efficiently, this project aims to identify molecular targets that may sensitize pancreatic cancer cells to gemcitabine. To achieve this goal and provide additional information regarding PDAC biology, this project will investigate the negative feedback mechanisms involved in MAPK signaling activation mediated by Dual-specificity phosphatases (DUSPs). Therefore, it proposes to evaluate whether the modulation of specific DUSPs presents any sensitizing potential against gemcitabine in pancreatic adenocarcinoma cell lines. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANTOS, Verena Silva. Effect of DUSP11 modulation on gemcitabine sensitivity in pancreatic ductal adenocarcinoma cell lines. 2018. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.