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Proteomics of schizophrenia: the search for biomarkers in platelets

Grant number: 16/23181-9
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): May 08, 2017
Effective date (End): November 07, 2017
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Wagner Farid Gattaz
Grantee:Helena Passarelli Giroud Joaquim Nadal
Supervisor abroad: Christoph W Turck
Home Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Local de pesquisa : Max Planck Society, Munich, Germany  
Associated to the scholarship:13/10350-9 - Proteomics of schizophrenia: the search for biomarkers in platelets, BP.DR

Abstract

Schizophrenia is a complex psychiatric disorder that affects about 1% of the world's population. Despite considerable progress in recent years, the etiology of the disease has not yet been clarified. The beginning and the progression of the disease are heterogeneous and often the patients' symptoms are common to other neuropsychiatric disorders, making differentiation and diagnosis through essentially clinical methods. So we have sought to identify measures based on molecular characteristics, which justify and explain the etiology of schizophrenia. There are already some studies with markers in the brain, but for this to be a material with limited availability; efforts have focused on finding a peripheral biomarker. This study aims to draw a platelet protein profile of drug-naïve patients in first psychotic episode. Will also be evaluated a group of healthy controls for comparison. To this end, the Proteomics is a good methodology whereas provides a complete profile of proteins at a given time and in a specific organism.