Triazolic 2-Aryloxazolines: synthesis of small libraries, biological activity, fluorescence and ligands

• Grant number: 16/24396-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: June 01, 2017
• End date: July 31, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Helio Alexandre Stefani
• Grantee: Mariana Pompilio Darbem Rocha
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The project will encompass multidisciplinary topics around a well defined class of compounds, where we hope to obtain within the period of the PhD the consolidation of the knowledge of synthetic organic chemistry of heterocyclics with organic photophysics, which will automatically result in analytical and biological applications. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA, ISADORA M.; ESTEVES, C. HENRIQUE A.; DARBEM, MARIANA P.; PIMENTA, DANIEL C.; ZUKERMAN-SCHPECTOR, JULIO; FERREIRA, ANTONIO G.; STEFANI, HELIO A.; MANARIN, FLAVIA. Iron (III)-Promoted Synthesis of Substituted 4H-Chalcogenochromenes and Chemoselective Functionalization. ADVANCED SYNTHESIS & CATALYSIS, v. 361, n. 13, p. 3163-3172, JUL 2 2019. (17/26673-2, 17/24821-4, 16/04289-3, 16/24396-9)

SANTOS, FABIANO S.; ZANOTTO, GABRIEL M.; ARGOMEDO, LUIS M. Z.; DARBEM, MARIANA P.; GONCALVES, PAULO F. B.; STEFANI, HELIO A.; RODEMBUSCH, FABIANO S.. Synthesis, experimental and theoretical photophysical study of proton transfer based oxazoline fluorophores. Potential tailor made optical sensors for enantiomeric detection in solution. DYES AND PIGMENTS, v. 165, p. 372-382, JUN 2019. (16/24396-9, 17/24821-4)

ESTEVES, HENRIQUE A.; DARBEM, MARIANA P.; PIMENTA, DANIEL C.; STEFANI, HELIO A.. Carbonylative Negishi-Type Coupling of 2-Iodoglycals with Alkyl and Aryl Halides. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 2019, n. 44, p. 7384-7388, NOV 30 2019. (17/26673-2, 17/24821-4, 16/24396-9)

DARBEM, MARIANA P.; ESTEVES, HENRIQUE A.; DE OLIVEIRA, ISADORA M.; STEFANI, HELIO A.. alpha,beta-Unsaturated 2-Ketoglycosides via Pd-Catalyzed Carbonylative Heck Reaction of 2-Iodoglycals. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 2020, n. 32, JUL 2020. (16/24396-9, 16/04289-3, 17/26673-2, 14/50316-7, 17/24821-4)

DARBEM, MARIANA P.; ESTEVES, HENRIQUE A.; DE OLIVEIRA, ISADORA M.; PIMENTA, DANIEL C.; STEFANI, HELIO A.. Palladium-Catalyzed Thio- and Selenocarbonylation of 2-Iodoglycals. CHEMCATCHEM, v. 12, n. 2, NOV 2019. (16/24396-9, 16/04289-3, 17/26673-2, 17/24821-4)

DARBEM, MARIANA P.; ESTEVES, C. HENRIQUE A.; DE OLIVEIRA, ISADORA M.; REIS, JOEL S.; PIMENTA, DANIEL C.; STEFANI, HELIO A.. Synthesis of d-glyco-alkynone derivatives via carbonylative Sonogashira reaction. RSC ADVANCES, v. 9, n. 17, p. 9468-9474, 2019. (17/26673-2, 16/04289-3, 17/24821-4, 16/02392-1, 16/24396-9)

DE OLIVEIRA, ISADORA M.; DARBEM, MARIANA P.; ESTEVES, C. HENRIQUE A.; PIMENTA, DANIEL C.; ZUKERMAN-SCHPECTOR, JULIO; STEFANI, HELIO A.; MANARIN, FLAVIA. Ytterbium-catalyzed formal [4+2] cycloaddition: Synthesis of chalcogen-quinolines 3-unsubstituted. Tetrahedron Letters, v. 59, n. 44, p. 3907-3911, OCT 31 2018. (16/04289-3, 17/26673-2, 16/24396-9)

DARBEM, MARIANA P.; KANNO, KARINA S.; DE OLIVEIRA, ISADORA M.; ESTEVES, C. HENRIQUE A.; PIMENTA, DANIEL C.; STEFANI, HELIO A.. Synthesis of amidoglucals and glucal esters via carbonylative coupling reactions of 2-iodoglucal using Mo(CO)(6) as a CO source. NEW JOURNAL OF CHEMISTRY, v. 43, n. 2, p. 696-699, JAN 14 2019. (17/26673-2, 17/24821-4, 16/04289-3, 16/24396-9)

DE OLIVEIRA, ISADORA M.; ESTEVES, HENRIQUE A.; DARBEM, MARIANA P.; SARTORELLI, ARTHUR; CORRERA, THIAGO C.; RODRIGUES-OLIVEIRA, ANDRE F.; PIMENTA, DANIEL C.; ZUKERMAN-SCHPECTOR, JULIO; MANARIN, FLAVIA; STEFANI, HELIO A.. Stereo- and Regioselective Cu-Catalyzed Hydroboration of Alkynyl Chalcogenoethers. CHEMCATCHEM, v. 12, n. 13, MAY 2020. (16/04289-3, 14/50316-7, 17/24821-4, 16/24396-9, 17/26673-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ROCHA, Mariana Pompilio Darbem. Carbonylative coupling reactions involving C2-glycosides. 2021. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.