| Grant number: | 17/11725-7 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | September 01, 2017 |
| End date: | December 31, 2019 |
| Field of knowledge: | Biological Sciences - Immunology - Cellular Immunology |
| Principal Investigator: | Ana Flavia Popi |
| Grantee: | Olívia Fonseca Souza |
| Host Institution: | Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil |
Abstract Hyperproliferative diseases, such as Chronic Lymphocytic Leukemia (CLL) and Systemic Lupus Erythematosus (SLE) are possibly related to some disturb in the apoptosis pathway, specifically in B-1a cells (CD5+). These problems result in the accumulation of B-1a cells in lymphoid organs, bone marrow or periphery, as observed in experimental models with old animals. Furthermore, it is known that aging increases B-1 cell population, although it is not yet elucidated if this happens due to self-renewal of mature cells or reactivation of the precursor cell. Based on this, this project aims to investigate parameters of the clonal expansion and/or hyperplasia of the B-1 bone-marrow-derived precursors. The main purpose is to identify possible alterations in the B-1 precursor cell that could be involved in the beginning of these hyperproliferative pathologies, with neoplastic or autoimmune basis. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
| More itemsLess items | |
| TITULO | |
| Articles published in other media outlets ( ): | |
| More itemsLess items | |
| VEICULO: TITULO (DATA) | |
| VEICULO: TITULO (DATA) | |