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Evaluation of B-1 cell precursor population in the aging: possible relation with hyperproliferatives diseases

Grant number: 17/11725-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2017
Effective date (End): December 31, 2019
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal researcher:Ana Flavia Popi
Grantee:Olívia Fonseca Souza
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Hyperproliferative diseases, such as Chronic Lymphocytic Leukemia (CLL) and Systemic Lupus Erythematosus (SLE) are possibly related to some disturb in the apoptosis pathway, specifically in B-1a cells (CD5+). These problems result in the accumulation of B-1a cells in lymphoid organs, bone marrow or periphery, as observed in experimental models with old animals. Furthermore, it is known that aging increases B-1 cell population, although it is not yet elucidated if this happens due to self-renewal of mature cells or reactivation of the precursor cell. Based on this, this project aims to investigate parameters of the clonal expansion and/or hyperplasia of the B-1 bone-marrow-derived precursors. The main purpose is to identify possible alterations in the B-1 precursor cell that could be involved in the beginning of these hyperproliferative pathologies, with neoplastic or autoimmune basis. (AU)

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