P53 and p21 expression in bone marrow clots of patients with megaloblastic anemia

• Grant number: 16/19725-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2017
• End date: June 30, 2018
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Cristiano Claudino Oliveira
• Grantee: Denis Nicolas Kwan
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The megaloblastic anemia has your ethiopathogeny based in the folate and/or cobalamin deficiency. The biopsy/clot of bone marrow is a diagnostic tool for cases in which the clinical-laboratory presentation can indicate others possibilities of differential diagnosis. The morphology context of this disease displays hyperplasia of erythroid series due to megaloblasts, which are cells from this lineage interrupted differentiation. The present study proposes to investigate, in concern with the literature, the pathophysiologics mecanisms of megaloblastic anemia by p53 and p21 protein expression by immunohistochemistry. This study is going to evaluate the link between immunohistochemical expressions of these markers with the clinical-evolution behavior of the patients. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KWAN, DENIS NICOLAS; QUEIROZ ROCHA, JULIA THALITA; NIERO-MELO, LIGIA; CUSTODIO DOMINGUES, MARIA APARECIDA; OLIVEIRA, CRISTIANO CLAUDINO. p53 and p21 expression in bone marrow clots of megaloblastic anemia patients. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, v. 13, n. 7, p. 1829-1833, 2020. (16/19725-3)