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Evaluation of the anti-Xanthomonas potential action of hybrid compounds of pirazinamide-chalcone

Grant number: 17/09233-9
Support type:Scholarships in Brazil - Master
Effective date (Start): July 01, 2017
Effective date (End): February 28, 2019
Field of knowledge:Agronomical Sciences - Agronomy - Plant Health
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Henrique Ferreira
Grantee:Caio Felipe Cavicchia Zamuner
Home Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil


Citriculture is an important economic activity in the country, with Brazil being the largest orange producer in the world. This production is threaten by a severe plant disease, the asiatic citrus canker, caused by the Gram-negative bacteria Xanthomonas citri subsp. citric. This disease is responsible for great losses to citriculture and its control is necessary. The eradication strategy, alone, with the removal of plants in affected areas, has been abandoned in the state of Sao Paulo. Nowadays, there is still none curative measures available to orchards and an integrated management approach is an option to stop citrus canker spread. The only chemical control available has been done with copper sprays, which brings contamination risks to soil and water sources. In this manner, alternative strategies for control are essential to keep the Brazilian citriculture competitive. In this context, this project aims to evaluate the anti-Xac action of hybrid compounds of pyrazinamide-chalcones - molecules which posses an antimicrobial potential. In order to assess this potential, these hybrid compounds will be tested to obtain its minimal inhibitory concentration (MIC) by REMA and its bactericide/bacteriostatic action by MBC tests. Subsequently, the active molecules will have its protective effect against the phytopathogen infection evaluated. Furthermore, Xac treated with these promising compounds will be inspected via microscopy, which may provide indications for the antibacterial action within routes of our research group interest, such as chromosome segregation, celular division and cell wall synthesis. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ZAMUNER, CAIO F. C.; DILARRI, GUILHERME; BONCI, LUCIA C.; SALDANHA, LUIZ L.; BEHLAU, FRANKLIN; MARIN, TAMIRIS G. S.; SASS, DAIANE C.; BACCI JR, MAURICIO; FERREIRA, HENRIQUE. A cinnamaldehyde-based formulation as an alternative to sodium hypochlorite for post-harvest decontamination of citrus fruit. TROPICAL PLANT PATHOLOGY, v. 45, n. 6, SI MAR 2020. Web of Science Citations: 1.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ZAMUNER, Caio Felipe Cavicchia. Potencial de ação de compostos como protetivos e sanitizantes contra o fitopatógeno Xanthomonas citri subsp. citri, causador do cancro cítrico. 2019. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Rio Claro)..

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