Effect of collagen V supplementation in rats joint with arthritis induced by methylated albumin

• Grant number: 16/25969-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2017
• End date: July 31, 2018
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Walcy Paganelli Rosolia Teodoro
• Grantee: José Eduardo de Castro Matheus Rodrigues
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Joint inflammation, generally described as arthritis (RA), affects the synovial joints of the body. It is typically characterized by the presence of local pain inflammation, swelling and stiffness, leading to limitation or loss of function of the site involved. The incidence of RA increases with age, reaching 85% of the population until age 64, and this fact results in a significant social impact and degree of disability. The etiology of RA types, where there is no associated autoimmune factor, is still unknown. It is known that in lymphocytic pathophysiology, a lymphocytic infiltrate and neoangiogenesis lead to the formation of the pannus, which affects subchondral bone and articular cartilage, with cartilaginous involvement being the major problem of RA. It is known that the treatment for RA needs to have an early onset in order to preserve the osteocartilaginous structure. Additionally, although the medications currently used have high cost and often side effects that limit its use, we postulate that a therapy that helps the treatment in the early stages of the disease would be of great value for the control of the evolution of the same. Recent studies in our group have shown that oral supplementation with COLV can modulate inflammation and remodeling of joint synovitis in rats. It is still known that the COLV can be exposed in processes of tissue remodeling, generating autoimmunity in several pathologies. Considering these aspects, our proposal will be to evaluate the effect of COLV supplementation on the structure and cartilage matrix of rats with arthritis induced by methylated albumin, in order to identify the efficiency potential of this protein as an alternative therapy in RA. (AU)