Immunization of LDLr - / - mice with electronegative LDL mimetic peptides: a potential therapeutic strategy for atherosclerosis

• Grant number: 17/06568-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: July 01, 2017
• End date: May 31, 2021
• Field of knowledge: Health Sciences - Pharmacy
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Dulcineia Saes Parra Abdalla
• Grantee: Gustavo Luis Tripodi
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 19/13598-8 - Immunometabolism as new approach to development of "natural adjuvants" that induce regulatory responses, BE.EP.DR

Abstract

Introduction: Among the various modified forms of low density lipoprotein (LDL), electronegative LDL [LDL (-)] is an endogenously modified subfraction that contributes to the atherosclerotic process, modulating the inflammatory response. Considering that the protein portion of LDL (ApoB-100) is targeted by autoantibodies, peptides derived from this antigen have been investigated for the development of a therapeutic strategy in atherosclerosis. LDL (-) mimotope peptides mimic the conformation of ApoB-100 epitopes exposed after changes in LDL that occur in the body, thus being candidates to be used in immunization for atheroprotectionRationale: Our group recently mapped two human LDL (-) mimotope peptides, termed p1A3 and p2C7, which represent conformational microdomains of ApoB-100 and modulate the inflammatory response of macrophages. Objective: To investigate the atopoprotective effect of p1A3 and p2C7 peptides through immunization in C57BL/6 LDLr -/- mice, in order to elucidate the immunomodulatory effect and contribute to the future development of a therapeutic strategy in atherosclerosis (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GOMES, RENAN AUGUSTO; FORNARI, EVELIN; SILVA ROCHA, ANA CAROLINA; TRIPODI, GUSTAVO LUIS; DA SILVA EMERY, FLAVIO; GOULART TROSSINI, GUSTAVO HENRIQUE. Parasitic sirtuin 2 as an opportunity in drug discovery. Future Medicinal Chemistry, v. 13, n. 16, p. 1397-1409, AUG 2021. (17/06568-0, 13/15650-0, 17/25543-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

TRIPODI, Gustavo Luis. Immunization of LDLr - / - mice with electronegative LDL mimetic peptides: a potential therapeutic strategy for atherosclerosis. 2021. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.